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HuskyMom3
03-10-2018, 04:55 PM
I am a new parent to Cushing's Disease in my 5 and half year old Siberian Husky, Duchess.
About 2 years ago, she appeared to lose her hair around her neck; we just assumed that it was from an allergy to her collar which she was not normally wearing a collar. Our groomer assured us it would grow back, never did. Then about 6-7 months ago, Duchess began to pee and drink excessively; she just couldn't hold her urine. I was concerned about hot spots as she was constantly cleaning herself. Country vet we took her to at the time; leaned down smelled urine and treated her for peeing as it is common in middle age dogs. Still wasn't happy with the outcome, so when finished meds didn't go refill and went to doggie diapers to hopefully save the carpet and her embarrassment when she couldn't hold it. In early December, I had to board the dogs for a month, while transitioning cities to be with my mother. The day I picked up Duchess, I cried. She had spots on her skin that hair was gone, she could barely walk, was trembling and looked like she might not back it through the night. I worried for a week until I could find a vet in my new location. I walked into the vet that first Saturday and the vet immediately looked at her and said endocrine disease! I was at once relived and terrified as my son's dog has Addison's.
We did the blood panel and it came back with high liver and it was suggested that we do the short test; although she has ALL the symptoms of Cushings. Surprisingly, the test came back normal for Cushings. We then waited for a couple of weeks, as she did have good days and bad days and did the full day test. I received a call the next morning that she had definitely tested for Cushing's Disease. We have immediately started her on Vetoryl 10 mg 2 x day. It is amazing the difference it has made in her! She is now "talking to her brothers"; engaging with other dogs at the doggie park, less peeing and drinking and some energy level back. Unfortunately, she is now losing plugs of hair and she has a rat tail as a husky but at least it is wagging again! The muscle mass is still not improved and she sometimes face plants when she overdoes her walking, hunting for moles or climbing out of the car.
The vet wanted to do another test after 2 weeks of meds, however, she also said based on her results from the short test, that we were really going to have to monitor by behaviors then test results. My thought is for now; to monitor her and keep her on the meds and then test after 30 days. It costs SO much to finally get a diagnosis plus meds; I need to save a little up since I only get paid monthly. Am I putting her at risk as long as I closely monitor for any changes.
Note: unfortunately, she did not get her undercoat this year; so she does lots of shivering not sure if do to cold or Cushing's symptom. I recently went out and got a doggie sweater and she loves it! Fact, when I try to take it off, she runs. Am I doing in harm covering up her hair is she is gaining bald spots? The vet told me that hair loss was not a symptom of Vetoryl; but that maybe the skin was finally repairing itself and that the hair loss was do to that. She has a "crusty feel to her entire skin now; or a bacterial infection of the skin. We are monitoring for the weekend to see if she really is going to be bald or just in spots.
For those of you that are old pros at this; can you give me any advice or am I going about this all the wrong way?
I was thinking that Cushings was a disease that treatment could give a better quality of life, but now I am seeing that life expectancy may be diminished due to the disease. Thanks for listening!

M&Inu
03-10-2018, 07:45 PM
Hi! I am new here too so I really can’t give advice, but I wanted to say that even if its a scary diagnosis, with the help from this group I am sure you will be able to help Duchess a lot! I am glad Duchess already is feeling better and her tail is wagging! :)

Harley PoMMom
03-10-2018, 11:48 PM
Hi and welcome to you and your sweet girl, Duchess!

I am sorry for the reasons that brought you here but so glad you found us. Could get copies of her tests and post those results here? With respect to the blood chemistry and complete blood count (CBC), you need only post the highs and lows and please include the normal reference ranges and we are especially interested in the results of the tests that were used to diagnose her Cushing's. How much does Duchess weigh? And was an urine sample collected for an urinalysis? Besides the PU/PD does she have any of the other common Cushing's symptoms such as a ravenous hunger, pot-bellied appearance, seeking cool places to rest, and/or panting? Is she on any other medications/herbs/supplements? Regarding the Vetoryl, is she getting it with a meal so that it is properly absorbed?

As far as monitoring ACTH testing, Dechra's official published protocol is to conduct an initial test at the 10-14 day mark. Then, as long as the cortisol level has not dropped too low, the recommendation is to remain at the same dosing level until the one-month mark. This is because cortisol levels have a tendency to continue to drift downward during the early days of treatment, even when the dose remains unchanged. However, we are finding that some specialists are holding off until the one-month mark to perform the first full ACTH test, unless of course, the dog is not behaving normally and/or looking well, than an ACTH stim test would need to be performed right away. It is also recommended that the initial starting dose of Vetoryl not exceed 1 mg per pound so with Duchess taking 10 mg BID, for a total of 20 mg, I am assuming that with her being a Siberian Husky she does weigh over 20 pounds, correct?

Cushing's can make dogs more vulnerable to infections of all kinds; bladder, ears, and skin. With your description of her skin being crusty it has me concerned a bit because there is a particular skin condition called Calcinosis Cutis that can strike dogs who have elevated levels of steroids/cortisol in their body. This condition can worsen very quickly and can be a bugger to get under control and the only way to really diagnose Calcinosis Cutis is with a skin biospy.

Cushing's is a treatable disease and with treatment dogs with Cushing's can have a good quality of life and there is every reason to believe that they can live out their normal life span. However, for the treatment to work safely and successfully it requires an educated pet owner along with an experienced vet as adverse side effects are mostly seen when the proper protocols are not followed.

Again, I am happy you found your way here and we will walk this journey with you and Duchess. If you have any questions please do not hesitate to ask them. :)

Lori

molly muffin
03-12-2018, 10:03 PM
Hello, and welcome from me to.

As Lori said the possibility is that it is cc, caused by calicum deposits. Do you see any sores, red and angry looking in the area of hair loss? The other possibility is with an endocrine disease that she has gotten a yeast or other type infection on her skin. This could be clearing up as the vet mentioned. Are you seeing any improvements? A coat is fine and often they do love them. Especially dogs that had an undercoat that didn't come in.

We do understand the money concerns, cushings is an expensive disease. When you said they did a short test, do you mean an ACTH test? There would have been two results a pre and a post result.
As Lori mentioned, can you post any abnormal values from blood and urine testings. That would help us to give you better feedback.

I would probably try to do slow walks to build up her muscles again. High cortisol levels can cause weakening of tendons and ligaments, and hind leg weakness is quite common. So, some swimming, slow walks up, not overdoing it could also help.

On the low end of giving 20mg a day, she is probably okay, but you will want to test to find out how her body is reacting to the cortisol. If you did an ACTH then you have a baseline to judge by.

It does sound like you have a vet who recognized what was going on with her and was able to address it so that is good.
I can't imagine an nonvocal husky. They just love to be yakky so I'm so glad she has found her voice again.