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Chippa
08-24-2015, 04:20 PM
Hello! My name is Rebecca and my husband and I adopted a 12 year old Fox Terrier named Chip in December 2014. Chip will be 13 on October 1st and in the last few months has started experiencing some really concerning things. Our vet called today and encouraged us to learn about Cushings, as she is beginning to think Chip may have it. I do not want to take away from anyone who is experiencing this with their pet, but I want to understand what may be happening to our family if at all possible. (I apologize for what is going to be a very long history, considering we have had him for less than a year.)

Chip has been a peculiar dog, and has un-explainable diarrhea 10-15 times a night, even with rounds of probiotic powder. He currently takes Metronidazole every other day which has an un-explained effect on his diarrhea and completely eliminated the frequency and urgency of his accidents.

We then thought Chip had a neurological disorder, or mass/lesion in his brain due to really frequent head/neck tremors and increased loss of balance. Neurological tests were inconclusive due to Chip's extreme dislike for the Clinic. He has had a great response to Phenobarbital and has shown a decrease in the frequency of the tremors. We maintain his Phenobarb dosage.

Shortly after, Chip started having muscle spasms in his neck and was put on Methocarbamol which eliminated those almost immediately. We maintain his methocarbamol dosage still as well.

Chip has very severe allergies and incredibly sensitive skin and while we try and avoid steroids as much as possible, he just finished a round of Prednisone that was helping with really serious itching. He also takes Zyrtec daily.

On Friday (8/21) we woke up to 3 diarrhea accidents in the house, as well as 3 puddles of blood filled urine (entirely red) and drops of blood all over our house. We immediately took Chip to the vet. The urinalysis showed extremely high levels of red blood cells (obviously) but also a really concerning amount of bacteria. An ultrasound of his bladder showed no masses, but that the walls of his bladder and his urethra were very inflamed. He was started on a 20 day (twice a day) round of Clavamox for the UTI as well as additional probiotic powder. He continued to pee/drip blood for the remainder of the day Friday, but has since had a great response to the Clavamox.

After getting him home Friday, he refused half of his lunch (which has NEVER ever happened). After refusing his food, he then threw up. We called the vet and they attributed it to stress from the earlier visit (understandable). He then threw up again about half an hour later and the vet called him back in for an anti-vomiting shot and a round of bloodwork.

The vet called today to check in, and share the results of his bloodwork. His blood work in December showed elevated liver enzymes (forgive me, I don't know which ones) at 300. This time, the same liver enzymes were at 900. The vet has now told us to look into Cushings and begin to understand it as the bladder infection, UTI, bacteria in his urine, and elevated liver enzymes could point toward Cushings. She said the Prednisone could also be causing some of these results, but that it was important to retest in about 2 months to check the liver levels.

I feel as though we have had a really turbulent year and Chip has been put through the ringer. It feels like nothing has been typical. The vet said Chip won't be a candidate for typical diagnostic testing because of his reactions when he is at the clinic so I don't know what to look for or what should be expected...any advice or help would be very appreciated, we feel like we are in the dark. Again, I apologize for the length of this.

Renee
08-24-2015, 07:35 PM
A few initial thoughts here, although I am sure some of the experts will be by with more in-depth comments.

1. - Chip needs a culture and sensitivity to determine the exact bacteria present in his urine and the proper antibiotics. The clavamox is a broad spectrum, but may not be appropriate. Case in point, my own cush pup had severe UTI's and needed a 5 week cycle of doxycycline to clear them up.

2. - that much vomiting and diarreah make me think that pancreatitis (both chronic and acute) may be at play. You can run a spec cPL test for pancreatitis. Also, may consider IBS as a cause of all the gastro issues.

Any chronic illness, coupled with recent prednisone use, is going to influence test results for cushings testing, so it's definitely smart to wait.

Harley PoMMom
08-24-2015, 08:46 PM
Hi Rebecca,

Welcome to you and Chip! Sorry, I have only a moment to post but Phenobarbital will elevate those liver enzymes, and it is highly recommended that dogs taking this should have their liver enzymes tested regularly.

I'll try to get back later...

Hugs, Lori

molly muffin
08-24-2015, 10:50 PM
Hello and looking at Chips history, the diarrhea over a long time and being on antibiotic, and being a fox terrier, I'm thinking underneath cause might be IBD as we have another foxy on here who has those types of symptoms when his IBD flairs ups. IBD dogs are Very sensitive to their food and need usually a single protein. Then peridocially with a flair they need the Metronidazole. The boody urine, etc, definitely a UTI and as Renee mentioned it is best to get a culture to find out what kind of bacteria it is. E-coli for instance can be very difficult to get rid of and you need to treat it specifically.
As lori said the pheno can also increase the liver enzymes as can the prednisone. Prednisone in fact can cause a cushing type called itrogenic in that it is caused by the steroid. How long was he actually on prednisone?

Those are some initial thoughts.

Everything depends on the dog. We've had some do well on years of treatment. For strictly cushings, we are not sure of at all at this point, you treat, get them regulated and go on about your lives. The symptoms of cushings most common are ravenous hunger, drinking buckets of water a day, urinating frequently and in the house when normally they wouldn't, thin hair, pot belly for example. You haven't really mentioned those things and not every dog has all the symptoms of course, but those are the normally seen one.

Chippa
08-25-2015, 12:56 PM
Thank you everyone for your replies. This has given us a lot to think about and explore for his care.

I will definitely ask our vet for more details on the urinalysis. We are going to run another one in two months, but maybe we need to have that retested sooner.

Whenever he takes it, he has the prednisone for about a month. First few days he takes it twice a day, a little bit longer on once a day, and then about two weeks of every other day to ween off. Today is his final day on the every other day pill, and he is finished with it.

Part of our vet's concern has been his insatiable appetite and trying to keep his weight under control. He will eat and within 20 minutes is frantically trying to get more, which is what made him turning away his food on Friday really concerning. This is consistent since we have had him. He drinks excessively, certainly increased on the Pred. but he has always been an excessive drinker, drinking for really long periods of time. We keep a homemade pedialyte formula in his water to make sure he is staying hydrated as he is on so many medications that could cause increased urination.

When we got Chip, he had been abandoned in a house for 9 months after his owner passed away. The family said they sent someone over to feed him once a day, but we aren't positive they even did that. He was in pretty bad shape when we got him. Part of that being that his potty-training had reversed, since he wasn't able to go outside. For a while he was having accidents in the house until we were able to re-train him. No issues for a while, but in the last month or so he has started having accidents in the house, whether diarrhea or urine. I'm having a hard time distinguishing what is an effect of aging, possible sickness, or possibly reverting back to old habits.

He had a very serious flea infestation while living alone, so his hair was in terrible shape when we got him, but it has since filled out and shined up with proper diet, so thinning hair isn't much of a concern. Our vet did mention that he didn't have any of the very noticeable symptoms (thinning hair or pot belly) which I hope is encouraging news, but I also know that not all animals will show symptoms the same way.

Currently the Metronidazole is the only thing keeping him from having explosive diarrhea multiple times a night (issues are condensed only to night). If he misses his metronidazole pill, he immediately begins having problems. We have found a diet that works for him, as he had allergic reactions to everything else we tried, including a really severe reaction to the ID Prescription formula. I will ask our vet about IBD, but he doesn't have flares necessarily, as he has ongoing issues without the medicine.

Renee
08-25-2015, 03:39 PM
Poor Chip! That food anxiety may be more behavioral / emotional than a physical issue. I have a rescue that was deprived of food his first 2 years. I've had him almost 10 years and he still has a lot of food anxiety. It gets better every year, but it's still there.