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FrankieandBlaze
12-01-2014, 02:14 AM
HI! I'm so grateful to have found you all!

Here is my story if you would take some time to read it.

I have a 13 year old Husky (Blaze) who was just recently diagnosed with Cushings. Looking back he has had symptoms for YEARS. He tore his ACL in 2011 without much reason, I imagine that was our first symptom... then last December I took him to our vet specifically because he was drinking a TON, peeing in the house and his urine was noticeably dilute, and a lot of it. He also had noitceably thinner hair, calluses on his elbow, and muscle wasting of his head. He has always had a huge appetite, but started stealing off the counter. At the time the vet did a urinalysis and blood work, said his liver enzymes were slightly elevated, but not worrisome, and we just chalked it up to old age. This summer he started panting A LOT, drinking more and more in house accidents...again we thought well, he's hot because it's summer and he IS getting older...then it all came to a head this fall. First he tore his other ACL...literally by walking up a hill in our yard. He was taking Rimadyl for pain, we did not do surgery (we did not feel at 13 he would tolerate it well, and our vet said his knee would naurally develop scar tissue which would stabalize his knee), he was not lame, and he rebounded fairly well naturally. Then he decided to try and eat a porcupine. He required anesthesia to remove the quills, before the anesthesia the emergency vet (not our normal vet) did blood work on him because he's elderly, they called and said his liver enzymes were 5 times normal (no I don't have the numbers, I'm going to call and get them tomorrow), and that his liver felt slightly enlarged. We stopped the Rimadyl immediately, and they prescribed him Tramadol for pain, and Denamarin and suggested a work up for his liver enzymes.
When I spoke to our vet the next day she suggested lots of things, xray, ultrasound, bloodwork and suggested it could be Cushings and that the Cushings could be causing his liver enzymes to be elevated. When I looked up Cushings symptoms I KNEW this was what he has, he has just about every symptom you could list with the exception of black head like marks on his skin...I wish I had looked this up a year ago OR that our vet had thought of this a year ago when I brought him in for these symptoms!
Given finances, we delayed xray and ultrasound, and asked if he could just start with blood work. They did the ACTH test (again, I'll get the results) but it came back positive for Cushings. And he is now on Denamarin and Trilosate 30 mg (he is a 70 pound dog) once a day. He has been on it for 3 days now...I might notice less panting, and more concentrated urine..but perhaps I'm wishful thinking so early on :) After 10 days we will repeat the test to see if there is any change.

My big question is this. We had assumed that his hind leg problems were due to old age. Since the stress and anesthesia of the porcupine incident he has not rebounded. He used to beg and follow us around and get up to the door when someone came, and now he does not, he has noticeable weakness in his hind legs and it is difficult for him to get up, and now that we have snow, it is difficult to walk outside. We have shoveled paths for him and built ramps so he can get in and out. His quality of life is not great, and while he doesn't seem uncomfortable, and appears happy and wags his tail, all he can do is lay around and go out to pee. So while I see many comments about how the drinking and peeing and ravenous eating can get better on meds, I'm wondering specifically about the muscle wasting, and decrease in strength, can I expect this to improve?

And one thing I'm wondering, could the stress of the porcupine and anesthesia made his symptoms worse so that he couldn't rebound? This happened on Oct 26, and he just is so different than he was up to that point (darn porcupine).

Thanks for your time,
I appreciate your input.

LauraA
12-01-2014, 02:30 AM
Welcome to you and Blaze :)

Back leg weakness and muscle wasting can be caused by Cushings and generally it does improve once the cortisol comes down, which can take some time. If it is caused by arthritis however, as the cortisone comes down it can make it worse. It can be a bit of a balancing game dealing with cushings/athritis and sometimes it is best to keep their cortisol a little higher than normal to deal with it. Hopefully Blaze's is caused by the Cushings and the trilostane does the trick, though it may take some tweaking to find the best dose him. That first stim test after 10 days will let you know exactly where he is at and if the dose needs to be increased.

FrankieandBlaze
12-01-2014, 03:09 PM
Thanks Laura, its hard to see him struggling. Its too bad we had to stop the rimadyl, it really helped him. Tramadol just makes him tired. More than anything though he appears to be lacking strength in his hind legs....I'm hoping that can improve some.

LauraA
12-01-2014, 08:50 PM
My girl took a good month to show improvement. in fact her panting and roaming at night got worse before it got better. I was so happy when she stopped wetting herself and we actually slept through the night lol. It looks like your vet has gone the right way in starting the dose low so there is less chance of any side effects and it may be he may need a little higher after his test :) How is Blaze going now? Hopefully you noticing some subtle changes.

My girl tore her ACL a few years back, decided she would try and catch a Kangaroo. I am sure the Kangaroo was laughing at this little fluffy dog trying to catch up with it. Fortunately we don't have porcupines here to worry about :D

Squirt's Mom
12-02-2014, 08:53 AM
Hi and welcome to you and Blaze!

Laura has done a good job of getting you started and I have little to add but did want to talk about the arthritis. As Laura said, lowering the cortisol is very likely to make the arthritis worse so he needs to be started on some support now if he's not already. There is a really good product called Glyco Flex that our surgeon put my pup on after her last leg surgery and she stayed on it the rest of her life. It has the usual glucosamine and condroitin as well as lots of other goodies not so common like green muscle lips. No script is needed. I would also get him on a good salmon oil like Nordic Naturals Pet. Watch for white potatoes, tomatoes, and other foods from the nightshade family in the diet as this family of plants can cause conditions like arthritis to be more painful.

It would help us a great deal if you would get copies of all the testing done so far on Blaze to diagnose the Cushing's and post those results here. We want to see anything that was too high or too low on the lab that shows things like ALP, BUN, etc. along with all the info that follows the numbers (little letters and normal ranges for each). On the ACTH we will need to see the 2 numbers (or 3 if in Canada). The LDDS, if he had one, will have 3 numbers.

How is Blaze doing today? Are you noticing any changes in him yet?

I'm glad you found us and know some of our Trilo parents will be along to chat with you. We were a Lysodren house. ;)
Hang in there!
Hugs,
Leslie and the gang

molly muffin
12-02-2014, 09:07 PM
Hello and welcome to the forum.

I definitely would go with the joint supplement that Leslie recommended as it helps alot. My girl has a couple problems with joints and she has been on it for quite a while. Some days are better than others. I added steps to the window seat and rails so she couldn't jump up and down. She will jump for treats if I let her. I try to keep it minimal for jumping but she wants to so she does.
That there was a change so quickly in the behavior after the porcupine incident makes me think that it's probably pain. The denamarin should help bring those liver enzymes down and hopefully once the cortisol is under control for a bit, you'll notice a change for the better in muscles. Some of the members have mentioned that their dogs are back to running and playing again, so we hope the same thing for Blaze.

Welcome again

FrankieandBlaze
12-11-2014, 08:59 PM
My 13 yr old Husky has been on Trilostane for 13 days. Today he is so weak he cannot stand up, he is trembling (not seizing), he did eat his dinner, he drinks water if you put it infront of him, my husband had to carry him outside. He is 70 pounds and has been on 30 mg/day. Is this a side effect of the drug? Our vet feels it is related to the progression of the disease and that we should keep him on the med. While he was just diagnosed, he has probably had Cushings for many years when looking back at the symptoms. He has been getting progressively worse over the last few weeks, hard to stand up, weak hind legs but today he cannot get up at all, can barely lift his head...I"m not sure if we should stop the med or not....at this point I'm not sure he'll make it through the night...
Thanks...

labblab
12-11-2014, 09:14 PM
I have just now merged your new post into your original thread. Absolutely, I would stop the trilostane immediately and seek emergency assessment for your boy. I cannot imagine a vet telling you to continue to administer the medication in light of your dog's collapse. The problem now may be exaggerated by low cortisol or it may be something completely unrelated to Cushing's. But you do not give trilostane to a dog that is acutely unwell. I think you need to get him professional help ASAP.

Marianne

Harley PoMMom
12-11-2014, 10:26 PM
I agree 100% with Marianne, please stop the Trilostane/Vetoryl. Do you have any prednisone on hand, if so, you could give him some and see if this would perk him back up, a 5 mg dose of prednisone would be adequate.

Please do keep us updated.

Hugs, Lori

FrankieandBlaze
12-11-2014, 10:38 PM
Thanks. I trusted my gut. My husband has him at the emergency vet now. They're going to check his labs,give him fluid, and most likely steroid. They had not given me any emergency prednisone but the emergency vet thought he probably needed more than just that anyway at this point. Kicking myself for letting it get to this. He's been getting weaker and weaker but i assumed it was his arthritis getting worse because the steroid was coming down. ....

Harley PoMMom
12-11-2014, 10:49 PM
This happens so please don't be so hard on yourself, you did good, you stopped the medication and have him at the vets, very good move. ;)

Let us know how he is doing, ok.

Hugs, Lori

Squirt's Mom
12-12-2014, 10:05 AM
Please let us know how he is doing....and let your vet know he was so very wrong. ;)