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View Full Version : Mia-Could she have Cushings?



parje1
05-24-2014, 01:31 PM
Hello Cushings Forum,

The K9Diabetes Group suggested I post Mia's diagnosis here and see if you had any suggestions.

Mia is an 11 year old, spayed Lab. She was diagnosed with diabetes on 1/21/14. She has been a super healthy dog until now. In December, she started to make this huffing and coughing noise. I took her to the vet and they couldn't find anything conclusive with xrays and bloodwork. Here's a video of what she sounded like.

http://s1097.photobucket.com/user/parje1/media/Mia/IMG_3730.mp4.html

At this point, she could still hike with us and had no exercise intolerance. She was starting to move a little slower. Over the next month, the noise didn't go away. They thought it might be a reaction to the pollution in our air. Winter air in Utah is bad. She was treated with antibiotics then Rimadyl. The Rimadyl was for bad days and it helped some.

I took her back the middle of January as the noise had not improved. They did bloodwork on her and found out she was diabetic. We started her on Humulin. That was 1/21/14

Since that time, Mia's health has continued to decline. She has lost 18lbs and she has back leg weakness. Her calories have been doubled and she is still losing. Voraciously eats her dinner but won't eat on her own and she eats out of my hand. She always lays down to eat. Sometimes her back legs seem to cross on her and she will drag a back toe. It's difficult for her to squat to poop. About the same time we started the insulin, she began panting alot about 2 hours after the insulin. I had read that was normal. It has progressed and she pants heavily in the night and is restless. She will be asleep and then she sits up abruptly pants for a few minutes, goes back to rest, and a few minutes later is back up again panting. She does pant during the day now but nights are always worse.

http://s1097.photobucket.com/user/parje1/media/IMG_3907.mp4.html

http://s1097.photobucket.com/user/parje1/media/IMG_3968.mp4.html

The huffing noise went away about 2 months after diagnosis.

She does drink alot but she doesn't have accidents in the house (we have two dog doors). She doesn't seem to need to go outside more often even though she drinks alot. I think it's alot of effort for her to move around. She has battled diarrhea or very loose stools for 3 months. We even tried another round of antibiotics and probiotics. The probiotics help a little. She no longer has puddles of liquid poop but they have very little form to them. At first there was some mucous in stools but not now. Poop is very stinky.

Mia has been xrayed 3 times and nothing has shown up. She's had 3 series of bloodwork done, fecal exams, several urine tests. At first, they thought she had LarPar or pancreatitus but the tests were negative. She hasn't had a UTI through all of this either. Then we thought it might be heart problems but negative also.

Mia was on Humulin for 2 months and then I switched to Novolin for almost 3 months. She is 50lbs now. She was at 21 units of Novolin. Her BG numbers never greatly improved. She typically ranges from 250-450. Once in awhile we will get a 150 number but it isn't typical. The vet didn't like the way she was responding to NPH and I had heard of some dogs not responding to a synthetic, so 3 days ago we switched to Vetsulin. Her numbers haven't changed nor has the panting but it's early to tell.

I have been also taking her to acupuncture when her back legs get wonky and it helps.

I asked the vet about Cushings and she said not likely. Here is her latest blood test. I'm sure you've all been down this road but I am running out of funds (I have another senior Lab with health problems). The vet has run so many tests that she kind of says now, I don't think it's this but we can run this test just to rule it out.

Would you mind looking over her information and see what you think?

http://i1097.photobucket.com/albums/g350/parje1/Scan00671copy.jpg

She doesn't have a pot belly (quite the opposite), she isn't losing anymore fur than normal, she doesn't have white patches, she does pant alot, has rear leg weakness, lost most of her muscle, and she has a hard time moving around, and loose stools for months. It's alot of effort for her to move around. She seeks out cold places, she has always been a nervous dog, she does this snake tongue thing, she still wags her tail, she has a slight arch to her back end but the regular and holistic vet didn't seem to think it was anything, and we haven't been able to find any sore spots as a source of pain.

Thank you,
Jen & Mia

goldengirl88
05-24-2014, 03:19 PM
Welcome to the forum. I am sorry your Mia is having troubles. She does have some symptoms: hind leg weakness, panting, lying on cool places. I see her alk phos is up but not greatly, a lot of the dogs we see have really high alk phos and alt. I noticed her platelets going up just a smidge which sometimes can indicate dehydration, which can happen with Cushings dogs. That being said my dog was not the typical case either as she had normal alt and slightly raised alk phos. Because you are having money worries the cheapest test you could have is a Urine Creatinine test done which would rule out Cushings, but does not diagnose it. Cushings dogs drink buckets of water and pee like crazy so I am just not convinced with the few symptoms you posted. Have you had a thyroid panel done? I am sure the others will be on and help with their opinions also. Blessings
Patti

parje1
05-24-2014, 03:39 PM
Thank you. She drinks alot but I wouldn't say buckets. Just frequently. She goes outside to pee about every 4 hours. We did have a thyroid panel done. It was all normal with elevated T4 which I know can be caused by the diabetes.

That's good to know that her alk phos is not crazy high. I don't really know what I'm looking for.

Thanks,
Jen

goldengirl88
05-24-2014, 03:45 PM
Some of the others that have been on the forum longer may have some other ideas of what to look for.

jxeno13
05-24-2014, 05:09 PM
Hi Jen! Welcome to the forum. I'm sorry your baby is having so many problems. I can't add anything...but I can tell you that you've come to the right place for wonderful people who can help you along. I just dropped in to say welcome and sorry for the circumstances with your baby that brought you here. The others will be here before you know it! :D

Hugs, Jo Ann and Eli

charpol
05-24-2014, 05:17 PM
My Silky Terrier Tino has been diagnosed with Cushings because of her hair loss, thirst, hunger, diluted urine distended tummy and high ALT (liver enzymes I believe) of 406 and high ALK Phosphates (adrenal)773. He also seems to have weakness in his back legs. He doesn't have many of the symptoms Mia has. He has other symptoms due to his age - 16 1/2 years old. Because of his age I chose not to treat him as I do not want to put him through the medications, possible side effects the constant monitoring and I understand it doesn't cure the disease, also the treatment is very expensive. He seems to be doing okay, I just love him and keep him comfortable.

My prayers are with you and Mia that you will find the correct diagnosis. Char

molly muffin
05-24-2014, 07:02 PM
Hello and welcome to the forum.

I've looked over Mia's lab results and I'm not seeing what we would normal see with cushings. That along with her urine being quite concentrated makes me think that what you are dealing with is uncontrolled diabetes.

Panting can be a part of diabetes that is uncontrolled and so can rear leg neuropathy.

http://diabetesindogs.wikia.com/wiki/Neuropathy


In diabetic neuropathy, nerves in the legs are progressively damaged, leading to tingliness, pain, numbness, and weakness or paralysis.

Symptoms are less common in dogs, but do occur. Many dogs have hind leg weakness when they are first diagnosed with diabetes. This is sometimes the symptom which brings the pet to the vet's office. It's often falsely attributed to "getting older" by the caregiver. What is also known as "diabetic neuropathy". [1] most often affects both rear legs and will progress symmetrically. With treatment and regulation, most dogs also have reversal of neuropathy [2]

This 1983 JAVMA abstract [3] indicates that both the neuropathy and low blood pressure returned to normal following the control of the diabetes with insulin.

It's also possible to have peripheral neuropathy as a result of continuing hypoglycemic episodes.

I hope that this new insulin you are trying will do the trick, otherwise, it is possible that you'll have to get more aggressive with the insulin and maybe do a combination of regular and rapid insulin to get her down to where she needs to be.

That is my layman thoughts at this point. Some of the others will pop in too and give their thoughts I'm sure.

Sharlene and molly muffin

parje1
05-24-2014, 09:33 PM
Thank you. I really appreciate you looking into this. The K9 Diabetes forum thought her symptoms were pretty severe for her BG's not being crazy high and we wondered if something else was wrong. I'm hoping the new insulin does the trick too. My best wishes to all of you and your pups :)

-Jen

molly muffin
05-24-2014, 09:42 PM
Well that was my initial though from trying to do some quick research.
I do bow to the expertise within the k9diabetes group though, as diabetes isn't something that I am as familiar with. That article that I posted to you, seem to suggest though that the leg weakness could get very bad if not controlled. If she has never been controlled, then that might be what is contributing to both issues, leg weakness and panting.

We are all learning as much as we can as we go, hopefully some of the ones who have been at this for like 10 years or so, will be in to take a peek at the labs and what you wrote about symptoms and give their feedback too.

Sharlene and molly muffin