Majah
10-10-2012, 01:59 PM
Hello everyone. I'm the proud mom of several Manchesters. We have had three Mannies with Cushings in the last several years, and lost two of them in the past two years. They were both 15 years old, which is a nice long life for a Manchester. Our first, Champ, had undiagnosed Cushings. Neither our local vet, who is usually very good, nor the OSU veterinary hospital caught the disease. He had all of the typical symptoms, and I suspected it was CSH, but testing returned normal levels so no treatment was given. As it was, Champ had a pretty severe heart murmur and when we took him for evaluation of the murmur, the specialist found a sizeable splenic tumor. Later that day, the tumor ruptured and he was hemorrhaging, so we made the sad decision for euthanasia. In retrospect, our local vet said she realizes now he did have CS. She has been researching the disease since Champ had it.
The other dog we recently lost, just in May, to complications from Trilostane toxicity. We'd been taking her to a specialist because her symptoms seemed to advance rapidly. Based on what I've read from you all here, it seems that she may have had a macro tumor which was made worse by the Trilostane. I had to stop the trilostane on my own because the specialist insisted that Pele stay on it. I think she was just one of those rare cases of a dog that doesn't do well on it. She was never right after that, and had had some other health problems before CS was diagnosed, but it was just heartbreaking to put her to sleep. Her quality of life was gone, she was incontinent of bladder and bowel, weak and just didn't want to eat. We knew it was time but it hurt so much to let her go. This was just last May.
Now, our other old boy, Guinness, is a fastidious and very smart dog. He was diagnosed with CS about 2 years ago. It started with the excessive drinking and hair thinning. He's been doing great on Lysodren, with no evidence of worsening symptoms to me until this past two weeks. He just saw the specialist about a month ago and lab levels were exactly where they should be. (don't have numbers with me, but doc said they were showing within normal limits for the cortisol level.)
Over the past two weeks Guinness has been having a problem with hindquarter weakness. He waits for us to carry him up the stairs and has trouble standing without support. I'm just devastated because he has been doing so well. So my question, after this longwinded introduction is... is it possible that he's experiencing toxicity on the Lysodren? He is such a clean dog, never pees or poops in the house unless he can't help it, and even then, you can see that it upsets him. This morning, he had a pretty runny poo in the house. This is what Pele did when she was toxic on Trilostane. She was knuckling her front paw like Guinness is with his back right leg, and was vomiting and had diarrhea. I'm waiting on the vet to call me back, but at this point I want to stop the Lysodren until the vet can see him. I know he's been on the med for a long time, but I just don't understand why the sudden change in his walking and the GI issues.
Thanks for this forum....
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The other dog we recently lost, just in May, to complications from Trilostane toxicity. We'd been taking her to a specialist because her symptoms seemed to advance rapidly. Based on what I've read from you all here, it seems that she may have had a macro tumor which was made worse by the Trilostane. I had to stop the trilostane on my own because the specialist insisted that Pele stay on it. I think she was just one of those rare cases of a dog that doesn't do well on it. She was never right after that, and had had some other health problems before CS was diagnosed, but it was just heartbreaking to put her to sleep. Her quality of life was gone, she was incontinent of bladder and bowel, weak and just didn't want to eat. We knew it was time but it hurt so much to let her go. This was just last May.
Now, our other old boy, Guinness, is a fastidious and very smart dog. He was diagnosed with CS about 2 years ago. It started with the excessive drinking and hair thinning. He's been doing great on Lysodren, with no evidence of worsening symptoms to me until this past two weeks. He just saw the specialist about a month ago and lab levels were exactly where they should be. (don't have numbers with me, but doc said they were showing within normal limits for the cortisol level.)
Over the past two weeks Guinness has been having a problem with hindquarter weakness. He waits for us to carry him up the stairs and has trouble standing without support. I'm just devastated because he has been doing so well. So my question, after this longwinded introduction is... is it possible that he's experiencing toxicity on the Lysodren? He is such a clean dog, never pees or poops in the house unless he can't help it, and even then, you can see that it upsets him. This morning, he had a pretty runny poo in the house. This is what Pele did when she was toxic on Trilostane. She was knuckling her front paw like Guinness is with his back right leg, and was vomiting and had diarrhea. I'm waiting on the vet to call me back, but at this point I want to stop the Lysodren until the vet can see him. I know he's been on the med for a long time, but I just don't understand why the sudden change in his walking and the GI issues.
Thanks for this forum....
MODERATOR NOTE: Your post has been manually approved so that members can start responding to you. Please check your email for a message from k9cushings. You will need to reply to that email so that your post go directly to the board and are not delayed waiting for approval. If you have already received and responded to the confirmatory email, please be patient. Your registration will be finalized shortly. Thanks and welcome!