Harley 14y/o Pom-PDH-Lysodren switched to Vetoryl (Harley has passed)

[Franklin'sMum]

Hi Lori,

I'm sorry to hear that some of Harley's levels are up. But you'll both get through this, and figure out what's going on.....and what to do next.

Remember Lori, we're all right here for you both, and you are doing such a great job.

Hugs to you both,

Jane and Franklin xx
________
MEDICAL MARIJUANA CARD (http://medicalmarijuanacard.info)

[mypuppy]

Hi Lori, Goodness, I was so saddened to hear all this going on with little Harley. Lori, I can tell you a very positive person and Harley should already know you are there for him every step of the way to hold his paw--lol. I know we always say here all our pups are lucky to have us, so I wanted to remind you of that once again--I don't even know you, but I do know you do sooo much for that little guy and love him with all your might. I hope all his recent issues resolve soon, soonest, and we can get a good report. In the meantime, try to be strong, and know we love you and Harley very much. xo Jeanette and licks from the Princess


Hi Jane,

Ahhh, thanks for checking in on us...Harley had all his tests done on 11/18. It will probably be another 10 days or more, bc of our Thanksgiving Holiday, that I get back the results for the UTK full adrenal panel.

I do have the results back from his Geriatric Senior Profile, cPLI, UPC, and I had his blood pressure checked too.

It seems his blood pressure meds are not controlling his high blood pressure :mad::(:eek: I noticed this 2 weeks ago, or thought I did bc his nose started getting dry and cracked again. At the pharmacy when I went to pick up his rx for his BP pills they were different, instead of being little blue pills these were little white pills. I asked the pharmacist about it and she said that they were the same thing just a different generic brand,(he takes amlodipine). I called his vet and she said the same thing...now I wonder. I mean I believe they are BP pills but I don't believe all generic pills are equal.

Well since his BP was 185 :eek::eek::eek: the UPC came back at 2.6(</=0.5) His last UPC done 9/2 was 0.6 when his BP was 140.

But on a brighter note his cPLI came down from 528 to 464; ALP was 1289, it now is 761 (5-131); cholesterol was 557, it is now 383 (92-324); but his ALT took a turn upward :mad: was 188, it is now 272 (12-118.) So I'm fearing the worse about his estradiol level, that has probably gone up too. :(

Looks like I'm going to have to research liver issues with the estradiol/estrogen connection. I have some but not indepth like I have the pancreatitis. I guess Dr O will be getting e-mails from me again. :eek::eek:

Well that's all I have for now, when the UTK results come back I'll post them as soon as I get them. :)

Love and hugs.
Lori and Harley

[Casey's Mom]

Just a quick note to see how you are doing and to wish you and Harley a very happy Thanksgiving - Casey and Desi wish you guys the best.

[Harley PoMMom]

Hi Casey, Harley and I are doing fine, we're plugging along :p Thanks so much for checking in on us, that was so very thoughtful of you.

Jeanette you're absolutely right, I have to stay positive...keep them good vibes going. :) And yes I love my boy Harley beyond any words can describe...but I am no different than you or anyone else here. ;):)

Leslie I don't think Harley has a groove :eek: I don't think he wants a groove. :eek::eek: Hopefully, eventually we'll find the right combination so Harley can get his groove back. :D

I did talk to his vet and we have decided to hold off changing anything, including his BP meds, until the UTK panel results come back. Oh, except his diet, his vet, I and Monica have decided to change his diet to a much liver friendlier one. Instead of chicken and chicken gizzards he will have fish (Tilapia) and eggs.

I did forget to include 3 other things on his tests that I was very happy about...his T4 came in at 1.1, up from 0.6 (1.0-4.0) and his USG is at 1.012 which is up from 1.006 (1.015-1.050) and the ph in his urine went down to 6.0 from 8.0 (5.5 -7.0).

So now we just sit and wait....(fingers tapping) :eek::eek::D

Much love to you all and big, big hugs.
Lori and Harley

[Franklin'sMum]

Hi Lori,

Here is a title about canine liver issues and estradiol

Lipoprotein binding to canine hepatic membranes. Metabolically distinct apo-E and apo-B,E receptors.
D Y Hui,
T L Innerarity and
R W Mahley
The article is here...http://www.jbc.org/content/256/11/5646.abstract

This is from the next one

The estradiol-stimulated lipoprotein receptor of rat liver. A binding site that membrane mediates the uptake of rat lipoproteins containing apoproteins B and E.
E E Windler, P T Kovanen, Y S Chao, M S Brown, R J Havel and J L Goldstein
Abstract
Hepatic catabolism of lipoproteins containing apolipoproteins B or E is enhanced in rats treated with pharmacologic doses of 17 alpha-ethinyl estradiol. Liver membranes prepared from these rats exhibit an increased number of receptor sites that bind 125I-labeled human low density lipoproteins (LDL) in vitro. In the present studies, this estradiol-stimulated hepatic receptor was shown to recognize the following rat lipoproteins: LDL, very low density lipoproteins obtained from liver perfusates (hepatic VLDL), and VLDL-remnants prepared by intravenous injection of hepatic VLDL into functionally eviscerated rats. The receptor also recognized synthetic lamellar complexes of lecithin and rat apoprotein E as well as canine high density lipoproteins containing apoprotein E (apo E-HDLc). It did not recognize human HDL or rat HDL deficient in apoprotein E. Much smaller amounts of this high affinity binding site were also found on liver membranes from untreated rats, the number of such sites increasing more than 10-fold after the animals were treated with estradiol. Each of the rat lipoproteins recognized by this receptor was taken up more rapidly by perfused livers from estrogen-treated rats. In addition, enrichment of hepatic VLDL with C-apoproteins lowered the ability of these lipoproteins to bind to the estradiol-stimulated receptor and diminished their rate of uptake by the perfused liver of estrogen-treated rats, just as it did in normal rats. The current data indicate that under the influence of pharmacologic doses of estradiol the liver of the rat contains increased amounts of a functional lipoprotein receptor that binds lipoproteins containing apoproteins B and E. This hepatic lipoprotein receptor appears to mediate the uptake and degradation of lipoproteins by the normal liver as well as the liver of estradiol-treated rats. The hepatic receptor bears a close functional resemblance to the LDL receptor previously characterized on extrahepatic cells.
from http://www.jbc.org/content/255/21/10464.abstract

This is a site about SARDS and adrenal function
http://www.petcarebooks.com/SARDS/FAQs/htm

I don't know if any of those are any help to you, they're all over my head:o

Good vibes your's and Harley's way,

Jane and Franklin xx
________
LovelyWendie (http://www.lovelywendie99.com/)

[Dollydog]

Just checking in and am glad you're being positive,
((HUGS))
Jo-Ann & my Dollydog angel :)

[Harley PoMMom]

Hi Jane,

Thank you so much for the articles...they are a bit over my head as well...:p so I'll have to look up some of those words. :D but the good vibes are always needed and appreciated!!

Hi Jo-Ann,

It is so nice to hear from you and it is so kind of you to check in on us. Yep, gotta stay positive, I know our pups feel when we are tense or nervous and I don't want Harley feeling anything but positive feelings from me. So we're just going with the flow. ;):D

Love and hugs.
Lori and Harley

[littleone1]

Hi Lori,

I 'm glad you did get some positive results from Harley's tests. I'm sure you are anxiously awaiting the results from his adrenal panel.

I know Harley is in excellent hands. You do such a great job taking care of him, and of course the rest of the crew.

I'm hoping everything turns out for the best.

The Corkster sends kisses to you and Harley. Extra big hugs from me.

[Harley PoMMom]

Hello My Dear Friends,

Harley's UTK results came back and they did not make his mommy very happy. I talked to Dr Owings (his GP), and we will be starting Harley on a maintenance dose of Lysodren. He will start at 80 mg 3X week but he is not starting this until Dec. 28th.

He already has an appt. to get his teeth cleaned (Dec. 23rd), which really needs to be done and he will probably loose some of them, so I don't want to start him on the Lysodren then have him under anesthesia, also Lysodren has to be given with a small fatty meal of some kind to be absorbed right, and with Harley's pancreatitis I will need time to figure this out, Monica Segal is helping with this too. Plus if everything goes well at work, I will have off from work from Dec 21st - Jan 4th, which is our Christmas shutdown and I can get an extra week off after that if need be.

I realize the Lysodren will not lower the aldosterone so I need to talk to Dr Owings about spironolactone. We did up the dosage of his BP med from 1.25 BID to 2.5 BID, so I don't know if this will have any effect on the aldosterone. I know elevated aldosterone causes hypertension and electrolyte imbalances...more research. :eek::p

Below are just his post results from the first UTK panel completed 5/1 and his last one completed 11/27. Hey at least his estradiol is coming down!! :)



.5/1..........................11/27.
12.9 ug/dl CORTISOL 26.2 ug/dl (6-18 ug/dl).
1.67 ng/ml ANDROSTENEDIONE 3.4 ng/ml (.24-2.90).
132.2 pg/ml ESTRADIOL 96.6 pg/ml (23.3-69.4).
1.15 ng/ml PROGESTERONE 3.9 ng/ml (0.22-1.45).
0.91 ng/ml 17 OH PROGESTERONE 1.68 ng/ml (0.25-2.63).
81.9 pg/ml ALDOSTERONE 576.0 pg/ml (72.9-398.5).


From the UTK Sheet 11/27.

These results indicate presence of increased adrenal activity.

Consider items 1-5. Item 6 would also be a consideration.

1) U/S and or endogenous ACTH.
2) Melatonin.
3) Melatonin Implants.
4) Lignans.
5) Maintenance dose of Lysodren.
6) Lysodren.

As always my dear kind friends...any advice, opinions, suggestions, thoughts...anything you say is always appreciated.

Much love and big hugs,
Lori and Harley

[labblab]

Gosh Lori, I'm sure sorry that the UTK results didn't turn out better. And the increase in cortisol from 12.9 to 26.2 is, unfortunately, pretty impressive! :(

Given that cortisol level, have you and your vet considered a full Lysodren load as opposed to maintenance dosing? I just worry that perhaps you're beyond the point where a maintenance dose is going to offer enough control...

Marianne

[Harley PoMMom]

The one thing that is always on the back of my mind is Harley's pancreatitis...how much does it skew the ACTH tests???

When I had Harley's last ACTH test done on 9/10 his post results were 12 ug/dl and the RR for canines from Anitech are 5.5-20.0 ug/dl, so yes Harley is still elevated but at 26 ug/dl not extremely. So I don't know, consider me stupid, :confused::) a worry wart but I want some/alot of wiggle room. :(

[littleone1]

Hi Lori,

I was so hoping that Harley's results would be good. I know how concerned you must be. You are such a caring mom. I really hope that everything will improve for Harley.

I wish that I better understood everything that happens to our babies and could offer some words of wisdom.

My prayers are with both of you so that Harley improves.

Corky and I are sending extra big hugs for both of you.

[StarDeb55]

Even with the pancreatitis, I have a tendency to agree with Marianne, I'm not sure a maintenance dose is going to get things on track. I'm also thinking that if Harley's cortisol is under better control, his pancreatitis might improve. You might ask the vet about that possibility. The other thing about running a load, with the pancreatitis concerns, you might load at the lower end of the 25-50 mg/kg range, realizing that it may take longer, but it may be safer for Harley in the long run.

Oops, forgot. Loading at the lower end would give you some "wiggle room" for the unexpected.

Debbie

[labblab]

When I had Harley's last ACTH test done on 9/10 his post results were 12 ug/dl and the RR for canines from Anitech are 5.5-20.0 ug/dl, so yes Harley is still elevated but at 26 ug/dl not extremely.
I guess my worry stems as much from the abruptness of the increase as it does from the value itself. It sure seems like a pretty big jump over a three-month time span. And with his cPLI showing a decrease, I'd be less suspicious that it is pancreatitis that is fueling the increase. But I do understand why you are feeling cautious about taking the plunge with Lysodren. And if maintenance dosing does not work out as you hope, you can always shift to a load a little further on, just as Debbie is suggesting.

Marianne

[BestBuddy]

Lori,
No advice just support. I have great faith that you will find the best treatment plan and I am sure you will research all the options leaving no stone unturned.
Jenny

[Dollydog]

Lori, I'm sorry that the results from the tests aren't better and ditto to what Jenny said already. I have no experience with Lysodren.
Jo-Ann

[Harley PoMMom]

I have no doubt that the high cortisol is wrecking some havoc on his liver considering the rise in his ALT...so your suggestions of a low-dose load is one I will ask Harley's GP about, and I am sure she will be for it...it's me being the scare-de-cat...actually it's the small fatty meals he will have to take with the Lysodren that alarm me, if has to do this twice a day what will this do to his pancreas...will this cause a flare-up...hmmm.

[Casey's Mom]

Hi Lori, sorry about the results and you have a shoulder here if needed!

Casey has her Lysodren pill cut into quarters of 125 mg each and I give each quarter in a small piece of bread with some peanut butter on it. She gets this at the same time she gets her meal so it really isn't a lot of fat but there is some fat in the peanut butter.

Hope this helps,

Love and hugs to you and Harley,

[StarDeb55]

My Harley doesn't get a "fatty meal" on lyso days. I make sure he eats an adequate amount of dinner. I, then, bury his lyso capsule in probably what amounts to a teaspoon of peanut butter, popping the PB dollop in his mouth off the end of my finger.

Debbie

[Franklin'sMum]

Hi Lori,

I'm sorry about Harley's results. I have no advice, but just wanted to add my support.

We're all here for you, and I know you'll get through this the same as you have with everything that has come before.

Thinking of you both,

Jane and Franklin xx
________
Vaaapp (http://essentialvaaappvaporizer.com)

[Squirt's Mom]

Dear Lori,

I am so sorry Harley's results weren't better...but they could have been worse... :o ...doesn't help much, tho, does it? :rolleyes:

I can't really offer much advise but because of my experience with Squirt and that tumor...any time Dr. O suggests this -


Consider items 1-5. Item 6 would also be a consideration.

1) U/S and or endogenous ACTH.

...my worry level jumps through the roof, especially when there has been an increase in cortisol like Harley has shown. I know Squirt's case is different and that she is a cush odd-ball, but that single recommendation saved her life...and totally changed her Cushing's perspective. Endogenous ACTH's are very good, I suppose, but they confuse me and I like the idea of eyes seeing inside the workings of the body, looking for any aberrations. JMHO, of course, and not one single doubt lurks in my heart or head that you will do less than the very best for you precious boy.

As for the amount of fats that would be added with the Lyso meals, I'm not sure that would pose a real problem. Monica can help you determine which type of fat(s) would both serve the need of absorption for the Lyso plus have minimal triggering affects on the pancreatic enzymes. An adjustment elsewhere in Harley's menu can compensate for the fat increase in his diet...if needed. ;) I know you are in good hands with Monica and she will be of great help to you with this.

Hugs and love,
Leslie and the girls

[mypuppy]

Dearest Lori, I will try to remain as positive as possible for you here, but I can only relate to how frightened you may be feeling at this point. Nevertheless, it is a shame we "your k9cushings family" cannot provide more support for you. At times, I feel so helpless and wish I can just reach out in a different way than just behind a forum-- I wish you and Harley would not have to be in this place at all so you can go on with life. Please know I keep you and the little guy in my prayers, and will be praying for his quick recovery, as I do for my precious Princess each night. Keep the Faith, and keep strong. Best regards and luv for both of you...xo Jeanette



I have no doubt that the high cortisol is wrecking some havoc on his liver considering the rise in his ALT...so your suggestions of a low-dose load is one I will ask Harley's GP about, and I am sure she will be for it...it's me being the scare-de-cat...actually it's the small fatty meals he will have to take with the Lysodren that alarm me, if has to do this twice a day what will this do to his pancreas...will this cause a flare-up...hmmm.

[Franklin'sMum]

Hi Lori,

Just wondering how you and the handsome little Harley are doing? Does he seem to be feeling well in a Harley sense? I do hope you're both (all) trotting along happily and healthily.

Best wishes,

Jane and Franklin xx
________
Anime bondage (http://www.fucktube.com/categories/102/bondage/videos/1)

[Harley PoMMom]

Hello My Dear Friends,

Well Mr Harley had to have 3 teeth extracted yesterday, :(:eek: and he is actually doing pretty darn good. :) Altho he didn't want to eat his diet that was formulated for him, so I had to make him scrambled eggs! :rolleyes: He is on tramadol (TID) for 5 days and clavamox (BID) for 7 days. This morning he had his scrambled eggs and alittle canned dog food and when I came home from work he ate alittle more canned dog food. I will try to get him to eat his formulated diet this evening. :rolleyes::)

Dr Owings (Harley's GP) and I discussed his Lysodren treatment and will be starting him on a maintenance dose of 80mg 3X a week when he is done with his clavamox. She called Dr Oliver and conferred with him as well and he agreed that with Harley having pancreatitis, that loading him is just too risky. We can always up his maintenance dose if need be.

Dr Owings also questioned Dr Oliver about Harleys elevated aldosterone, it is 576.0 (72.9-398.5), he said that is most likely due to the amlodipine (BP meds) that Harley is taking to keep his blood pressure under control. Which I might add that yesterday at the vets office it was 150 and that was with no BP meds taken that morning. Harley is a "bugger" to poke a pill to. :o

Dr Owings told me that they are going to start using the Cortrosyn now instead of the gel for the ACTH tests!! :)

Harley and I wish all of our dear friends and their furbabies a Merry Christmas and a Happy New Year. :)

With much love and big, big hugs,
Harley, Lori, Bear and Alex the bad cat. :D

[littleone1]

Hi Lori,

I'm glad Harley is doing good today. :) I don't think he's in any pain since he is eating.

He is a little trooper. I hope everything goes well with the Lyso treatment.

I'll talk to you soon.

You and all of your babies have a very Merry Christmas.

[SasAndYunah]

Hi Lori,

I was checking how Harley did with his "dentist" visit and read that he had 3 teeth extracted :eek: Makes the one tooth Yunah had extracted look like peanuts :D I was so fortunate to be able to stay and watch throughout the entire procedure and mannnnnn just extracting that one tooth was "hard" work due to the length of the root. Took quite some force to get it out. Did they put stitches in Harley's jaw as well? They do bounce back so quickly, don't they? Yunah was the rest of the the Wednesday totally out of it but the next morning she was totally back to being her old self :D

I am truly sorry that Harley's other issues are so complicated and causing you so much worries. Unfortunately I have no wise words to offer since his issues are so far out of my league. All I do have to offer are some big hugs and wishing you and your loved ones a Merry Cristmas too :)

Hugs,

Sas and Yunah :)

[Franklin'sMum]

Hey Lori,

Big gentle hugs to Harley, and I'm so glad he's eating ok. (scrambled eggs :) you are such a good mummy)

Hugs all around, and thank you so much for your help,

Jane, Bailey, Franklin and my folks xxxxx
________
Curvy live (http://www.girlcamfriend.com/webcam/curvy/)

[Squirt's Mom]

Hi Lori,

What a shame Harley had to lose 3 teeth. :( Poor little fellow. I do hope he is feeling much better now and getting back to his usual old self.

The Lyso plan sounds like a very good one to me. That is what Dr O recommended for Squirt if she ever needs it. I know you will handle it with no problems what-so-ever; Harley is in excellent hands!

I wonder if there is another BP med that wouldn't impact the aldosterone...or is that just the nature of the beast? Have you asked if Monica has any dietary suggestions? Not sure there is one but it's worth checking into and I am sure she would know. Seems like I should know that...:rolleyes:

Hope you and yours have a very Merry Christmas!
Hugs,
Leslie and the girls - always

[Harley PoMMom]

Harley does have stitches, but you wouldn't know it, he wanted to play with his toys last night :eek::eek: He kept bringing me one toy after another and I had to keep explaining to him that he was not allowed to play. :(

I did email Monica and she did email me back!!:D:D We have a revised diet and Dr Owings has lowered his BP meds too, from 2 whole pills twice a day to 1 1/2 pills twice a day. It has made a difference, I think the 2 whole pills was too much and that he was getting tired of the rice...spoiled pup. :) But I love him dearly...and Harley usually gets whats he wants...within reason, ofcourse!

Dr Oliver said as long as his electrolyte's on his Chemistry panel check out ok, not to worry about that aldosterone being high. So every 3 months we will be getting Harley's electrolyte's checked.

Thanks for the vote of confidence in me, Leslie...I need it. :eek::D

Merry Christmas to all.

Love and hugs,
Harley and Lori

[Casey's Mom]

Your Harley is such a sweetheart, and he must be feeling really well to want to play with all of this toys,

Merry Christmas to you and yours Lori

Love and hugs,

[frijole]

Just saw that Harley had some teeth removed and wanted to send some cyber hugs and a shout out. Hang in there Harley! And Mom too! ;) Merry Christmas! Kim

[Franklin'sMum]

Hi Lori,

Just wanted to let you know I'm thinking of you and sending good thoughts your and Harley's way, always and especially today with starting the Lysodren maintainence dose.

Love from
Jane, Franklin and Bailey xxx
________
W201 (http://www.mercedes-wiki.com/wiki/Mercedes-Benz_W201)

[Harley PoMMom]

Hi Jane,

Aww Jane, you are such a sweetheart, thinking of us when you have everything going on with Franklin and Bailey.

Harley's on his antibiotic until Wednesday (30th) and his GP, Dr Owings is on vacation that week also, so we have decided to start him on his Lysodren maintenance dosage the week of Jan. 4th. :) I really want her around for this and she wants to be here when Harley starts his Lysodren too, but her vacaction was already planned months ago...hey they do have a life after all!! :p:) and I think I'm paying for some of that vacation she's taking!! :eek::) so I hope she comes back very refreshed. ;)

Love and hugs,
Lori

[kaliuma]

Hey Lori, Just getting caught up on everyone else's stories! Hope all goes well with Harley's lysodren treatment.

Best wishes for a healthy new year,

Susan (Kiska's mom)

[mypuppy]

Hi Lori, awww poor little Harley, sorry about his teeth. Would you please give him lots of kisses all over his precious little face and tell him Princess the chocolab sends lots of licks as well...lol....Hope you both at least had a nice holiday. We luv ya, xo Jeanette and Princess

[Franklin'sMum]

Hi Lori,

How are you and Harley going? Today is the 5th over here, so thinking it's the 4th over there...just wanted to give you some best wishes and positive thoughts (and calming breaths) for you and Harley.

Please keep us posted,

Jane, Franklin and Bailey xxx
________
Kitchen Measures (http://kitchenmeasures.com/)

[Harley PoMMom]

Hi Jane,

Thanks so much for the best wishes, positive thoughts and calming breaths, they are needed bc today Harley did start his maintenance dose of Lysodren. So far so good!! :) He will get his 80mg of Lysodren every Monday, Wednesday and Friday. A stim test will be done in three or four weeks unless one is warranted sooner. He'll have his electrolytes checked as well. Since Harley's been taking the pepcid ac he's been eating alot better. :)

So, our Lysodren journey begins!! :eek::)

Love and hugs,
Lori

[Franklin'sMum]

Hi Lori,
I'm so happy for you both that things are going well so far, and very much hope it continues :) I know how worried you were (and probably still are) but sweetie, look at everything that's happened up to this point... the testing, the testing, the worry, more testing, the dx, the terror and learning all you can to help your precious boy (and helping all of us here too) and how incredibly great you got through all of that, huh?
We have confidence in you Lori, and remember we are here for you for any thing.

Big big (((hugs)))

Jane and the gang xxx
________
Wicca Advice (http://www.religionboard.org/wicca/)

[John II]

Dear Lori,

This must be a tough day for you.
How long did you pause on that first pill?
Hope all continues to go well for you and for Harley.

[labblab]

Dear Lori,

I've got all my fingers crossed that Harley will do well with his Lysodren! As John has said, I'll bet you did hear a drum roll in your head before launching off...but in your wonderful and watchful care, I feel certain that he'll do just fine. :)

Many "good luck" hugs to you both today,
Marianne

[Roxee's Dad]

Hi Lori,

Keeping everything crossed that Harley does well with his new regimen. We have such confidence in you and your excellent care for Harley. He is certainly in good hands. :)

Give Harley a belly rub from me and mine. :)

[Squirt's Mom]

Hi Lori,

All this carrying on over Lyso in your loving, capable, knowledgeable hands...phooey :rolleyes:

Harley will do just fine because you are his mom. You will do just fine because you have educated yourself, prepared yourself, and you know about the most important things like listening to your gut. Harley couldn't be in better hands. He and I have the utmost confidence in you as ya'll start this new phase of his treatment.

:p But just in case :p .....

Sending lots of prayers, good wishes, hugs and love for you both,
Leslie and the girls - always

[Harley PoMMom]

You all are so wonderful!!! :D

And that "long pause" on the first pill, well, I think Mr Harley must of read my vibes bc he takes all his pills in cream cheese with no problems BUT when I tried with the Lysodren...he sniffed it, turned his little head away and walked away from me!! :eek: So I had to use potato bread, he loves potato bread...so I put the cream cheesed covered Lysodren capsule in the bread and then he would take it...no chewing, just swallowing it whole! Thank goodness. :) Poops are normal, his eating is good, and he ran after Alex the bad cat today, so we are doing pretty darn good!

Thanks so much for all your prayers, good wishes, hugs, and crossing of all assorted body parts!! They are very much appreciated and needed. And Harley has been getting extra belly rubs too!! He thanks you all so very much!

Love and hugs,
Lori and Harley

[Casey's Mom]

Lori you will do just fine with the Lysodren and Harley - you are a pro and certainly know enough going in to make it all easier for you. Casey is doing just fine on it thanks to all the info and experience I have gained on this site and I know you will do an excellent job.

Have faith in yourself and your knowledge,

Love and many hugs to you and Harley,

[littleone1]

Hi Lori,

I'm so glad to hear that Harley is doing good.

I have to chuckle at what we go through to get these little ones to take their meds.

Harley is in excellent hands. You are such a wonderful mom.

Extra big hugs and kisses from Corky and me.

[Dollydog]

Hi Lori,
It's a big day...that first pill. Glad it went down with the potato bread. Will be checking back for updates on this part of your journey with Harley.
Hope you both have a great sleep...
Jo-Ann & my Dollydog angel :)

[Casey's Mom]

Hi Lori,

Just wondered how Harley was doing this morning. Sending good thoughts and warm wishes.

Love and hugs,

[mypuppy]

Hi Lori, I am sorry I have not checked in on you and that beautiful faced little guy lately until just today only to find he has started his treatment again. Hey Lori, I know exactly how you felt having to restart. You always wonder if you are doing the right thing, but we can only hope we are. As many others here have mentioned, I too, believe you are such a special "mom" to your pup, and if he had the power to tell you in words, I know he would be telling you "I LOVE YOU MOMMY" every single day of his life. I hope his treatment goes well, and we will be praying for that much for both of you....Take care of you, and extra TIGHT hugs for both of you...xo Jeanette

[k9diabetes]

If you find that the pill is announcing itself through the bread or other coverings, we have started using empty gelatin capsules purchased online to put my cat's pills in.

They come in a lot of different sizes so even if it has to be a big one, you might be able to find a capsule that can cover up the pill. The capsule blocks the taste and the smell so my cat doesn't notice there's a pill inside of it.

My cat has one round pill that doesn't quite fit in the capsule but I crack the side of the capsule and stuff the pill down into the capsule so that it covers most of the pill. I don't think this would work for his pred as that is the really bad tasting one. I'd have to get a bigger capsule to be sure to cover the pred all the way if the pill was bigger. But this round pill is not all that obnoxious and the half capsule covers it enough to keep it from dissolving into the cream cheese.

He took his pills in just cream cheese for a long time but after a couple of times of his finding the pill in there, he started turning his nose up at the cream cheese altogether. So the capsules have worked perfectly for him.

I got mine at www.capsuline.com (http://www.capsuline.com).

Natalie

[Harley PoMMom]

Thanks Natalie for that link, so far the potato bread & cream cheese mixture is working for the Lysodren capsule! So this makes Harley's 2nd time and he is doing great, I took a vacation off from work tom. so I can be at home with him...just incase...me the worry wart!!

Thank you Ellen, Terri, Jo-Ann, Jeanette and Natalie for checking in on us, we are doing good. All of you are the best. :D

Love and hugs,
Lori and Harley

[littleone1]

Hi Lori,

I'm so glad that Harley is doing good.:) I know we worry so much about these guys. Enjoy your day off. Harley is in such good hands.
I know you are watching him very closely. He'll love having you home with him.

Take care. Extra big hugs for both of you.

[Casey's Mom]

Good for you Lori, enjoy your day off and try not to worry too much. Your Harley has the sweetest face - yeah I could look at that all day.

Love and lots of hugs,

[mypuppy]

ps: Lori, I loveeeee potato bread tooo...haaaaaaaaaaaaaaaaaaaaaa.
tight ones. xo J.

[forscooter]

Trying to play catch-up, which is almost impossible around here! :eek: But I wanted to see how the loading was going. Two dogs and a few reloads and I never ever liked it! It was the worst waiting and watching and waiting and watching and having the patience of a flea on three pots of strong coffee didn't help matters!! I wished it had been me so at least I could have known how I was feeling....

I also went through many snacks, changing them often bc the little buggers caught on if I used the same thing all the time....so I understand the battle and the relief of finding something that works!

Hang in there....we all know you can both do this with flying colors!!:)

Much love and many hugs from all of us to all of you!!!
Beth

[Franklin'sMum]

Hey Lori,

Just peeking in to send love and thoughts to you and Harley.

Jane, Franklin and Bailey xxx
________
Fix ps3 (http://fixps3.info/)

[Squirt's Mom]

Hey Lori,

I know you and Harley are doing just great, so.....

YEAH!!!!! Way to go Mom!! :cool:

But, of course, we do want regular updates anyway. :p Harley will be so happy his mom is home for a day to spend with him.

Keep your chin up!
Hugs,
Leslie and the girls - always

[Annie's Mom]

Annie and I send lots of positively thoughts to Harley!
Barb (Annie's Mom)

[Casey's Mom]

Hi Lori,

Just wondered how you and Harley are making out on your loading. :)

Love and hugs,

[Harley PoMMom]

Hi Ellen,

Dr Owings (Harley's GP) had a long conversation with Dr Oliver and they both agreed that a maintenance dose of Lysodren will be tried on Harley first, mainly because we all do not think his pancreas will be able to sustain a loading period. So we are trying this 80mg (once a day) of Lysodren every Monday, Wednesday and Friday and if this does not bring his cortisol down sufficiently then we will up the dose and go from there.

The pancreas is a very touchy organ once it has been agitated. I know when Harley had his teeth extractions and wasn't eating, and I took him back into see Dr Owings, she reran his bloodwork...his pancreas enzymes on Nov.18 were all within normal ranges, the ones done 12/30 the pancreas enzymes were really, really high. Now, I know this was from the anesthesia and pain meds, but it doesn't take much for the pancreas to flare-up. So, altho I know I am using a very conservative dose of Lysodren with my boy Harley, I am also keeping his pancreatitis in check...hopefully. Please keep us in your thoughts and prayers and thanks so much everyone for checking in on us, it means so much to me and it is so appeciated.

Love and hugs,
Lori and Harley

[Franklin'sMum]

Hi Lori,
Keeping you in our thoughts and prayers, always. Hoping Harley's pancreas is coping (well, not just coping, but thriving :))
Jane and the gang xxx
________
butt Cam (http://www.girlcamfriend.com/webcam/anal-sex/)

[forscooter]

Checking in on you, Lori....and we have everything crossed hoping that this will be the right dose to do the trick! And that the pancreas behaves too!!!

Love ya! Beth

[mypuppy]

Hi Lori, was thinking of you and Harley and hoping he's doing well so far with this treatment. Do keep us posted please. Princess is fine and still off the trilo. Dr. Lori's strict orders....lol....Thank you so much again for that. It meant so much to me....KIT. Luv, xo, Jeanette

[Harley PoMMom]

Thank you all for keeping us in your thoughts and prayers, they are greatly appreciated.

Harley is doing great...eating well, pooping nicely formed turds :eek::p:D and still wanting to play and keep Alex the bad cat in line! So his mom has calmed down a tad ;):o and hoping that in two weeks when we have his ACTH tests done that them numbers will be right on! :rolleyes: Yea right! Like that ever happens with us cush parents!!

Hoping all furbabies are doing well and their moms and dads too.

Love and hugs to all,
Lori and Harley

[littleone1]

Hi Lori,

I'm so glad to hear that Harley is doing so good on the Lyso. You need to think positive thoughts that his numbers will be in the normal range.:)

[Casey's Mom]

Thanks for letting us know that Harley is doing great - wonderful news!

Love and hugs,

[Franklin'sMum]

Hey Lori,

Just seconding Terri and Ellen's thoughts and well wishes. Great news, and thanks for letting us know,

Big hugs,
Jane and the gang xxx
________
Tl1000s (http://www.suzuki-tech.com/wiki/Suzuki_TL1000S)

[Squirt's Mom]

Hi Doll,

See, I knew you would sail through this like a pro! Never had any doubts at all!

Keep up the great work!
Hugs,
Leslie and the girls - always

[Harley PoMMom]

Hi Everyone!

Thought it was time for an update! Harley had his ACTH stim test 1/22 and his results were: pre-3.7 & post 18.5. Which is a significant drop from last post of 26 from the Nov UTK panel. We have raised his Lysodren maintenance dose from 80mg to 90mg, still given 3X a week.

His next stim test is scheduled for 2/26 and he will also be getting a cPLI plus a CBC/Chemistry panel done. His BP checked out at 175 :mad::eek: but we are only giving him 2.5mg amlodipine a day because when I give him more BP meds he doesn't want to eat. :( We are hoping if we get his cortisol down then his BP will come down and if not...then we will take this bull by the horns too! :cool:

We only had 2 episodes :eek: where he threw-up...once I think he just ate too much to fast because what came up looked like what he just ate! :eek: The other time I don't know, I give him his Lysodren when I come home from work so I have all night with him. This last time I gave him his Lysodren Monday at 4:30pm like usual and he was fine. I got up Tuesday morning, he was fine, and went to work. I came home and Harley had thrown-up on my bed...twice...white thick stuff. :eek::( but he was fine...wanted to go potty...drink and food. :) then play :D Called his vet and she said to give him the Pepcid AC the morning after the Lysodren too, so we are trying that.

Well that's it for now, except that it's snowing like heck...almost 8inches so far...I hate shoveling!! :eek::eek::)

Love and hugs,
Lori and Harley

[littleone1]

Hi Lori,

I'm glad to hear that Harley's cortisol levels are coming down. I hope his blood pressure improves. His little tummy upset might be due to the Lyso. Corky is still taking 1/2 a tablet of Pepcid AC daily, and he has not gotten sick from the Trilo. I hope the Pepcid AC also helps Harley.

Give Harley a big hug from me and kisses from Corky.

I hope you don't get too much more snow!:eek: I also use to hate the shoveling!:D I don't miss it now, especially with the winter you've been having.

Take care my friend.

[Franklin'sMum]

Hey Lori,

That's good news on Harley's cortisol level. :):) Not so good on his BP :(. I remember you had changed his BP meds a while ago, and said that you didn't think all BP meds were created equal, could his current BP med be at issue? (No idea, just throwing it out there.)

I hope Harley's slightly increased Lyso dose agrees with him, and does the trick.

Love and hugs to you and Harley,

Jane and Franklin xx

[frijole]

Lori, Are you giving the lysodren AFTER the meal or with the meal? AFTER will help prevent upset tummies. Also I found that wrapping it in something such as peanut butter, cream cheese helps coat the stomach as well. Kim

[Harley PoMMom]

Hi Kim,

This is our routine :p Harley gets his Pepcid...I wait 20-30 minutes and give him some of his food, then I give him his Lyso wrapped in cream-cheese and potato bread :rolleyes: then he eats the rest of his food. Sometimes, tho, he doesn't eat the rest of his meal :confused: Maybe he's getting fussy as he's getting older??

Love and hugs,
Lori and Harley

[frijole]

Could be an age thing I guess. You are certainly doing everything the right way (of course)!

[Franklin'sMum]

Hi Lori,

It's been ages since you last posted about Harley.....How's about an update, please? How is Harley's tummy these days? Hoping all is well in your world,
Big Hugs,
Jane, Franklin and Bailey xxx
________
DEPAKOTE LAWSUIT SETTLEMENTS (http://www.classactionsettlements.org/lawsuit/depakote/)

[Harley PoMMom]

Hi Jane!

Yes, it has been a while...oh where to start :eek: Harley has not had any tummy upsets! YAAA! But his last stim results on 2/26 were high...a post of 30 ug/dl :eek: I was so upset. :( His vet and I were stunned, stumped, and surprised at his results, as his last post was 18ug/dl on 1/22.

We decided to keep him on the 90mg of Lysodren until we could figure out what the heck was going on with him, so she called a refill in for Harley, you see, the compounding pharm. is only 10 minutes away from where I live.

So, I go and pick up his Rx...pay for it...open it up before leaving and see that they gave me coral-colored capsules this time! :confused: I ask them if color of capsule means strength of dose, he says yes... Last time Harley's 90mg compounded Lysodren was in Hot-pink colored capsules...hmmm. I ask about this and they will get back to me...this is on Saturday.

Sunday my phone rings and it's the pharmacist...he tells me according to Harley's record that they have written they gave me coral colored capsules last time. Well I tell him I know the difference between hit pink and coral, and that my dog has cushings and his ACTH stim test results were higher than expected. I ask him if he can tell me what dose/strength of Lysodren Harley did take for 4 weeks.

Well, of course he says, just give him the lot number of the pill bottle. :eek::eek: CRAP...Harley took his last capsule Friday night, and I threw out the empty pill bottle in the trash. My boyfriend took my trash with him; my boyfriend's company has a huge trash bin and he takes my trash there every Sat. (Trash bin is in Maryland and I live in PA.)

So, the pharmacist has no idea what Harley took. Harley's vet was livid, she was going to call them and raise holy heck and see if she could get some answers. I told her not to bother, Thank God that Harley is ok.

Harley is now taking 125mg of Lysodren, which I cut a 500mg pill in quarters. I just talked to his vet on Sat. as she was wondering how he was doing on the 125mg dose. I know his cPLI numbers are sure coming down...WooHoo!! From 528 to 303!! :) Just gotta get that cortisol number down too...working on it. ;):)

Thanks for checking in on us, Jane!

With much love and big hugs,
Lori and Harley

[Spiceysmum]

Hi Lori,

What a shock for you. It's bad enough having to treat Cushings without having to worry if they are getting the correct medication. You would think they would know what strength comes in the pink capsules or are they doubting whether it was Lysodren at all?

At least Harley seems ok apart from his rising cortisol results, thank goodness.

Linda and Spicey

[Nathalie]

Hey Lori,

I would be beside myself knowing that the pharmacy may have screwed up the dose and by Harley’s test results that seems to be a very good possibility – yikes.:eek::mad:
With a post of 30 ug/dl Harley must be ravenous. Hopefully the new dose with bring the cortisol down.
Excellent that tose cPLI numbers are coming down.

Have a great weekend, :)
Nathalie

[Tamarah]

Lori -

What a pharmacy horror story. I would still be livid at the very least. They couldn't tell you the dosage of the hot pink pills? I would think that would be easily answered. Upsetting. And what if....what if the error was in the other direction? Maybe I shouldn't have brought that up, but it's a reminder to us all to question everything - even the correct color of their meds.

Harley is doing better now - still cortisol issues, but he seems to be doing o.k. now since the human blunder and that's good news!

Tammy, Crash, and Darby

[frijole]

Wow Lori.. that is scary. Good thing "Mom" is on the ball and not easily fooled. Imagine someone who wasn't... whew. Hope Harley's numbers come down now that things are straightened out. Hugs, Kim

[Squirt's Mom]

Holy Crap! That is terrifying, Lori! :eek: OMG! I would probably had one of my feet stomping, teeth baring, foaming come-aparts on that pharmacist! grrrrrrr..... How dare him play CYA after putting Harley's health at risk?

Then after the melt-down, I would be bawling my eyes out for being so mean. :rolleyes:

I hope you see a reduction in his cortisol with the new meds and no harm is done.

Big Hugs,
Leslie and the girls - always

[Harley PoMMom]

I was so mad and I wanted to yell and scream at that pharmacist...but I figured that would get me no answers, the pharmacist basically told me that he does not know what Harley took for 4 weeks, if it was Lysodren at all. :eek: He did ask me to call him and let him know how Harley is doing and the results of his next stim test.

You know a while back I thought Harley's light appetite was due to his BP meds, and you all know we made an adjustment to his meds for that bc they are known for that. Well I am believing that it is bc of his elevated cortisol instead.

When his cortisol was post 12ug/dl his appetite was ravenous and the higher it gets, his appetite wanes. He has lost 1 pound in 1 month.

April 9th will be his next stim test and I hope it shows that his cortisol is coming down...I do see signs...he is eating more. :) Wish us luck and Thank you all so very, very much...We Love You ALL Very Much!!!

Love and hugs,
Lori and Harley

[littleone1]

Hi my dear friend.

I'm keeping everything crossed that Harley's next stim test will show good cortisol levels.

[Franklin'sMum]

Lori,

OMG!!! :eek: Honey, I'm so glad Harley is ok, aside from the cortisol rise. How could the pharmacy make a mistake like that? To stuff up the dosage is seriously terrifying, but then to turn around and tell you they don't even know what medicine they gave him?! :mad::mad: :mad:

I'm with Leslie about the foaming at the mouth fury (but in that situation I don't think I'd be upset about being mean to them :o)

Thank goodness Harley is ok, and great news on his cPLI results :D:D:D:D and that his appetite is back :D YAY!!! Thank you for letting us know, Lori.

Big hugs to you both (oops, can't leave out Bear and Alex), so big hugs to you all,
Jane, Franklin and Bailey xxx
________
JUSTIN BIEBER FAN (http://justinbieberfan.info/)

[Roxee's Dad]

Hi Lori,
Just catching up and holy crap!!!!:eek::eek::eek:

Glad your on top of things but who knows what Harley has been on? Thank goodness he's okay. Sounds like a mix up to me, I wonder who might have recieved the prescription meant for Harley?

[Casey's Mom]

Gosh Lori that is really scary!! Glad he is okay but wow - that's a very bad mistake for a pharmacy.

Take care,

Love and hugs,

[Harley PoMMom]

Hello my dear and wonderful friends!

With nothing new really going on it has been a while since I updated Harley's thread. Well, Harley will go in for a stim test on June 2nd to see where he is at, his weight will be checked and then June 6th we will commence with the loading!

We will probably start him at 50mg/kg range, I am taking 2 weeks off of work and I only have 2 weeks to get him thru this. Dr Owings has given me dexamethasone shots plus I have the pred if an emergency arises.

Please keep us in your thoughts and prayers because with Harley not having the typical cushing's symptoms of excessive drinking and the ravenous appetite, his mom will be a nervous wreck until the loading-phase is over. :eek:

Love and hugs,
Lori and Harley

[Nathalie]

Yikes Lori - I would be a nervous wreck too.

So if Harley does not have any typical cushings symptoms what are you using as a gage to determine weather or not he is loaded?

Keeping toes and fingers crossed that all goes well,
Nathalie

[Harley PoMMom]

Poop patrol is one thing! :p:eek::D and I will start to with-hold 1/2 of his normal food portion to make him hungry. Not the ideal situation but whatcha gonna do? His last stim test done 4/11/2010...post 42.8 ug/dl, we then upped his lysodren maint. dose to 125mg 4X a week. But I don't think this has made a bit of difference...we shall see. :(

[gpgscott]

Lori,

I can't believe I missed this all. It is inexcusable that the dose was filled wrong.

So it appears you are at a starting point again.

This is the problem with compounded meds.

I don't think you should change the amont of food offered though, I would not change anything, just dose and observe.

Scott

[mypuppy]

Hi Lori,
I will be thinking of you and your Harley and have great faith all will go smoothly for both of you. Need I remind you in the same way you always remind the rest of us here--"you are a wonderful mom". Warmest regards and much love, xo Jeanette

[Roxee's Dad]

Hi Lori,
We will be thinking of you and Harley. I have no doubt that you will be able to keep on top of things.

[Casey's Mom]

I will be waiting to see how everything goes with your loading - very nerve racking with Harley not showing the typical signs.

Something Casey did when over loaded - went to the water bowl, stuck her tongue in and then walked away - very strange. Another thing that she did that I see mentioned here is the staring into space - almost as if she is thinking about something but staring at nothing.
Two symptoms you can watch for - I am happy that you were able to take some time off work for this.

Good luck and lots of hugs for Harley.

Love and hugs,

[Spiceysmum]

Hi Lori,

Good Luck with the loading. I have the utmost faith that things will be fine. Will be watching for updates.

Linda and Spicey

[Franklin'sMum]

Hi Lori,

Sending good thoughts your and Harley's way. I'm so glad you were able to get some time off work to watch Harley. Please keep us updated.

Love and HUGE hugs, and wishing the best for you both my friend
Jane, Franklin and Bailey xxx
________
Lesbian Licking (http://www.fucktube.com/categories/736/licking/videos/1)

[Squirt's Mom]

Hi Lori,

You and Harley will be in my thoughts and prayers in the coming days tho I am sure you will sail through this with no problems whatsoever!

Hugs and love!
Leslie and the girls - always

[Harley PoMMom]

Harley is on his 3rd day of loading and so far so good. His vet wanted to start him at 35.11mg/kg and I said that was too low...I wanted to start him at 50 mg/kg and she thought was to high for him so we compromised and he started at 46.81 mg/kg. Which means for his weight of 23.5 (10.68 kg) he is getting 250 mg 2X a day...works out well since I have to cut pills.

No signs of being loaded...nice formed poops and he is eating good which I am thankful for...just watching him and hovering! :p;):D

Wish us luck and please keep us in your thoughts and prayers for a successful and uneventful load.

Love and hugs,
Lori and Harley

[Roxee's Dad]

Hi Lori,


Wish us luck and please keep us in your thoughts and prayers for a successful and uneventful load.

All of the above and more.

[Tamarah]

Lori -

Checking in to see how your day is going. As hoped, it's uneventful and going well for you and Harley. Thinking of you here and sending you extra hugs and belly rubs (for Harley). :D

Tammy, Crash, & Darby

[mypuppy]

Dearest Lori,
I am so glad things are going well so far, and of course we will hold you and your precious little boy in our constant thoughts and prayers. What else can we possibly do for two very special beings. We wish you both, Bear included, every bit of good health and everything good life has to offer. Luv ya bunches, tightest hugs. Jeanette and licks from my Princess

[frijole]

Lori, You are doing great! Glad you went with a higher dosage. Keep us posted. Hugs, Kim

[labblab]

Lori, tons of "good luck" wishes from our house to yours!!!

Marianne, Peg and Luna

[lulusmom]

Thinking about you and Harley and sending positive vibes your way.

[acushdogsmom]

...so we compromised and he started at 46.81 mg/kg. Wish us luck and please keep us in your thoughts and prayers for a successful and uneventful load.The dosage sounds good to me. It's close enough to 50 mg/kg/day and still lets you easily divide the pills.

Lots of good wishes for an easy, successful and uneventful load from me, too! :)

[Mrs. J]

Wishing you ALL good things! :)

[BestBuddy]

Lori,
I have great faith in your abilities to watch and understand what is going on so I know Harley is in great hands. Hope it all goes smoothly.
Jenny

[marie adams]

Hi Lori,

We just went through the loading last week and tested late Monday; so still waiting for results. You are an expert at this I am a novice, but it really doesn't matter it is still nerve wracking to watch for the littlest sign. I wonder if a vet had to do the watching if they would have a different mind set of the process--haha!!! I know after the test on Monday late and running out of time for the day--still too many things left to do---I told my daughter I can't do this again because I still wasn't positive I had fully loaded her and then turn around and think maybe her numbers were low because of more shaking in her hind legs----arg!!!!:confused::confused:

I know you will sail through with flying colors!!!! :):)

[Harley PoMMom]

Well, I think Harley is loaded...went to give him his Pepcid in potato bread, which he loves, and he sniffed it and turned away! He never turns down potato bread! I am calling the vets office as soon as they open to schedule his stim test for Friday. I am so hoping for good stim numbers, please keep your fingers crossed! :)

Love and hugs,
Lori and Harley

[AlisonandMia]

Fingers crossed this is "it"! How many days has it been?

Alison

[mytil]

Fingers crossed here too Lori!

[Franklin'sMum]

Hi Lori,

Wishing you a easy and uneventful load for Harley. So glad to hear all is going well so far, you really are an excellent mum, Lori.
Happy hovering :p

With love,
Jane, Franklin and Bailey xxx
________
Motorcycle tires (http://www.motorcycle-tech.com/tires/motorcycle-tires)

[frijole]

Eyes, fingers and toes crossed. Hugs from Annie and I - Kim

[Harley PoMMom]

Fingers crossed this is "it"! How many days has it been?

Alison

He's had 4 days of 500mg (250 mg BID). Not only is he turning his nose up at potato bread but also almost all his favorite foods. I made different foods in advance that I could give him by hand to try to judge also if he were loaded. He is taking some of these foods with a "soft mouth" instead of the "almost biting my fingers off."

He is still drinking water normally and his poops are still nice and well formed...but I can tell he is off. His stim test is scheduled for Friday at 4:40 pm since his last dose of Lysodren was at 7pm Wed...not quite 48 hours post pill but that's the best they could do. I'm thinking of having them run a chemistry panel also.

Thank you all so much for your support as it really does mean alot and is appreciated greatly.

Love and hugs,
Lori

[marie adams]

Yeah!!! :):)

Maddie continued to eat and drink and poop a-ok, but I did notice a slight slow down in eating. It was the taking from the hand that changed also to a softer mouth.

I had to go with a little under the 48 hours, but it still worked.

[sunimist]

I've got everything crossed that is crossable for a loaded Harley!! We need a good ol happy dance right now!! GO HARLEY!!! :D

Shelba and Suni

[acushdogsmom]

Hoping for right-where-you-want-them numbers result on Harley's stim test. :)

[gpgscott]

Hi Lori,

Sorry to have been AWOL, sound like a mini load in progress?:(

Hope the stim is in the range.

Scott

[Casey's Mom]

Sounds good Lori!!

Love and hugs,

[brandysmom]

Hi Lori,

All fingers and paws are crossed! I hope you get the results you need for Harley's stim test. Best wishes and take care.

[Harley PoMMom]

Well...Harley is not loaded :( pre is 11.5, post is 18.3 :eek: and with him continually not eating properly reloading him is going to be a challenge but it must be done. I also have made a appt to have an ultrasound done on him. It is scheduled for this Friday at the Chesepeake Vet. Referral Center in Maryland. With his vets approval I have started him on 5mg of Reglan to help with any nausea that he may be feeling and hoping that this will start him to feeling better and eating more.

His liver enzymes levels are thru the roof...ALP 5450 (10-150) ALT 977 (5-107). His kidney, glucose and electrolyte values are all within normal ranges...thankfully.

My poor boy. :( please keep us in your thoughts and prayers.

Love and hugs,
Lori and Harley

[labblab]

Oh Lori. I'm so sorry that the test results were not better. The ultrasound does sound like a good idea, and I'll definitely be holding you guys in both my thoughts and prayers.

Big (((hugs))),
Marianne

[mypuppy]

Hi Lori,
I too am sorry Harleys treatment is not going as smoothly as one would expect. It really is a bummer when we don't get the results we want. Wow you are travelling all the way to Maryland for an ultrasound. If you don't mind my prying what is the ultrasound for and why there? I will definitely keep your boy in my thoughts and prayers and that you get some answers to whatever is going on with him. I can't say this enough but you are a wonderful mom and you and the other moms here inspire me to be just that to my Princess. Hang in there and sending you those tight hugs as always. Xo Jeanette and a lick from the Princess

[Casey's Mom]

Oh dear Lori - that is upsetting. Let us know about the ultrasound and hopefully soon Harley's tummy will feel better with the meds. Fingers and paws crossed . . .

Love and many hugs,

[zoesmom]

Shucks, Lori. Definitely not loaded. But he's in good hands and will keep all digits crossed for something soon. Yes, why the u/s? Sue

[Tamarah]

Lori-

So sorry to hear that Harley is having such a tough time and loading didn't go as hoped. :( Fingers, toes, paws all crossed for you and Harley. Extra hugs coming your way too.

Tammy, Crash, and Darby

[Buffaloe]

Lori,

I am sorry Harley's numbers are still high. I think the ultrasound is an excellent idea. As I remember, he had a small nodule on his right adrenal gland back about a year and a half ago. They probably recommended a follow-up ultrasound at some point anyway.

I believe his cortisol numbers have come down some with his 4 day load. To me, that is encouraging. A dog with a significant, functional adrenal tumor may very well just laugh at that amount of Lysodren. I'm hoping Harley does not have an adrenal tumor.

Ken

[Harley PoMMom]

The Reglan is definitely helping as Harley ate 2.5 oz. of chicken baby food and 1/4 can of dog food...YAA!

I want the U/S done to get a good look at his gall bladder, liver and his right adrenal gland. His last U/S showed that his R adrenal gland did have a 8mm nodule growing on it and I need to see if this is growing. Also trying to figure out why he is losing his appetite...could it be due to his gall bladder? liver? or what? Oh our poor pups :(

Although that post of 18.3ug/dl is high, it is a heck alot better than the post of 49ug/dl he was at! But we have a ways to go to a post of 5 ug/dl that he needs to be at.

Thank you all for your support as I don't know what I'd do without you all.

Love you all so much,
Lori and Harley

[frijole]

Lori, You know I can soooo relate to the issues of eating and loading. :(

In one of the articles I read on pancreatitus it mentions different drugs that can actually spring it on - there are many and it mentioned specifically that "chemo drugs" can cause a flare up. It didn't define which one(s) and I am wondering if this is what we are seeing?

I am no expert on this but it caught my eye and when I read your news it reminded me. Thoughts?

Meanwhile, hang in there. Remember it took Haley 4 mos to load (2 1/2 of daily doses) so sometimes it is just the dog. Meanwhile I feel your pain and send you big big hugs. Kim

[marie adams]

Oh Lori,

We are sending good thoughts your way. :D:D It is amazing when you see the changes, but the numbers do not. You already went through the stress and now it starts again. You have been there for us and we are there for you!!:) Harley is in your good hands and he knows it!!:) Good luck with the u/s I hope you get goods results.

Hugs and lick kisses

[trander27]

As a newbee sending you lots of positive thoughts and prayers. Your post have been so helpful to Marley and I. You and your crew here are the gold standard of loving pet owners.

[Harley PoMMom]

Lori, You know I can soooo relate to the issues of eating and loading. :(

In one of the articles I read on pancreatitus it mentions different drugs that can actually spring it on - there are many and it mentioned specifically that "chemo drugs" can cause a flare up. It didn't define which one(s) and I am wondering if this is what we are seeing?

I am no expert on this but it caught my eye and when I read your news it reminded me. Thoughts?

Meanwhile, hang in there. Remember it took Haley 4 mos to load (2 1/2 of daily doses) so sometimes it is just the dog. Meanwhile I feel your pain and send you big big hugs. Kim

Hi Kim,

It seems that Annie and Harley are having the same issues; pickiness with food, upsetting tummies, not drinking alot of water...hmmm.

When Harley's cortisol began to rise his vet called Dr Oliver. He suggested a maintenance dose for him bc of the existing pancreatitis. When we started his maint. dose his post cortisol was 26.2ug/dl. After 4 weeks of 80 mg Lysodren (3X a week) his cortisol came down to 18.5. Then the issue with the compounding came into play and I don't know...it's been a lost battle with his cortisol.

I believe the Lysodren could be a possibility for his inappetence but I want the U/S done to make sure that there is nothing else going on that could be making him feel the way he does. I will ask that they run the spec PL test to check his pancreatitis and see how this is responding to the Lysodren loading.

Big hugs to you and sweet Annie as I know you are going through similar issues with Annie...it is just so tough making these decisions and knowing if they are the right ones. :(

Love and hugs,
Lori and Harley

[Casey's Mom]

Hi Kim and Lori,

I just read the same thing about high Lipase values being related to chemo drugs. Hmmmmm Lysodren? No word yet from the vet regarding Casey's high Lipase and Amalyse levels but am trying to lower with diet.

Good luck Lori. Hugs to you,

[Harley PoMMom]

Just got off the phone with Harley's vet and she said she is going to call the IDEXX lab and have them run the spec PL test on Harley's blood. IDEXX Lab. is who they send their samples to...crap I never even thought of this...my mind is mush right now. He was fasted for over 12 hours that day bc he wasn't eating. She said we should have the results in a day or two. At least this will tell us how his pancreas is dealing with the Lysodren.

[apollo6]

good luck.

[frijole]

Just got off the phone with Harley's vet and she said she is going to call the IDEXX lab and have them run the spec PL test on Harley's blood. IDEXX Lab. is who they send their samples to...crap I never even thought of this...my mind is mush right now. He was fasted for over 12 hours that day bc he wasn't eating. She said we should have the results in a day or two. At least this will tell us how his pancreas is dealing with the Lysodren.
Is it possible for your vet to contact Idexx to see if lysodren has been shown to affect the pancreas?

[Harley PoMMom]

Is it possible for your vet to contact Idexx to see if lysodren has been shown to affect the pancreas?

I will definitely ask her if she can do that. Thanks Kim, that would be very, very important information to know.

[AlisonandMia]

I don't believe that Lysodren affects the pancreas - not even in humans where really, really high doses are sometimes used (to treat adrenal cancer).

I think the reference to "chemo drugs" would refer to the more all-round cytotoxic meds - meds that can potentially attack every cell in the body (most chemo agents would be in that category). Lysodren is strange though in that it really only affects the cells of the adrenal cortex and leaves other types of cell alone. In large doses it can affect the CNS - presumably because the CNS is so "fatty" and Lysodren loves to latch onto lipids.

I see Harley's cortisol has come way down (even though it is still way high) so I wonder if some degree of cortisol-withdrawal isn't possible?

Alison

[Harley PoMMom]

Got Harley's spec PL results...900!! :eek::eek: This is the highest these numbers have ever been. No wonder he doesn't want to eat. I am so glad that I am getting that U/S done.

He also has some kind of growth growing between his toes on his front right paw so I took him in to his vet. She believes that it may be a tumor but since we are going to see the IMS tom. she did not want to put him under and do any kind of surgery to remove it.

Hopefully the IMS will have good news tom.

Love and hugs,
Lori

[frijole]

Sending warm thoughts your way. Give Harley a big kiss from us.

[mypuppy]

Lori,
Thinking
of you and Harley and just praying all will be well with him. We do love you both sooo much. Jeanete and the Princess

[Casey's Mom]

Lori - I hope and pray for the best for you and that cutie pie Harley.

Love and hugs,

[apollo6]

praying your little guy will be well. Dealing with a lump under Apollo's tail myself.

[Tamarah]

Lori -

Good luck to you and Harley today. We're thinking of you and sending you and Harley an extra big hug. :)

Tammy, Crash, & Darby

[Spiceysmum]

Lori,

Sending lots of good luck to you both. We are off on holiday for a week so I hope to see good news on our return.

Linda and Spicey

[zoesmom]

Thinking of you and Harley today. Hope the vet gets things sorted out and that the toe problem is nothing much either. Sue

[Harley PoMMom]

Finally home! Dr Petrus went over the u/s with me and everything looks ok...I will have the full written report on Monday. Harley's liver is definitely enlarged but he didn't see any masses on it, pancreas looks ok for a spec PL report of 900! No blockages anywhere or lesions. The nodule on his right adrenal gland has gotten smaller, both kidneys and his spleen looked ok. Since bacteria was found in his urine when his urinalysis was done last Friday Dr Petrus performed an u/s guided cysto.

He looked at that growth on Harley's paw and gave me a rx for an antibiotic and said to wash/soak it in diluted solution of betadyne/betadine and to keep applying the triple antibiotic ointment to it. If the growth doesn't get smaller than an invasive treatment will have to be looked at.

He was stimmed again because I did start reloading him on Tuesday but had to stop on Thrusday because of his inappetence.

When Dr Petrus and I were first talking about Harley and his Cushing's symptoms I remarked about how Harley doesn't drink excessive amounts of water. Dr Petrus' remark was that not all dogs with cushing's disease will have excessive thirst, all dogs are different.

Love and hugs,
Lori and Harley

[AlisonandMia]

When Dr Petrus and I were first talking about Harley and his Cushing's symptoms I remarked about how Harley doesn't drink excessive amounts of water. Dr Petrus' remark was that not all dogs with cushing's disease will have excessive thirst, all dogs are different.



Nice to have that from the horse's mouth as it were! Kim's Haley never had that symptom and neither does Annie - and I think Glynda's Lulu at one stage had highish cortisol and really elevated intermediates (during and after the trilostane-to-Lysodren washout) and actually had to be encouraged to drink enough (I think that's right - correct me if I'm wrong, Glynda!) When humans are on steroids (anti-inflammatory dose anyway) it isn't something that you really notice either whereas most dogs would have a river running through them after a day or two.

Alison

[sunimist]

Glad you got some answers and hopefully the doc can make the little guy all better. Also hope the a/b and wash clear up the little paw without having to do surgery on it.

Hugs and kisses to Harley and a few hugs to mom too!

Shelba and Suni

[Franklin'sMum]

Hi Lori,

I'm so sorry to read that Harley has had some setbacks :(

Harley's liver is definitely enlarged but he didn't see any masses on it, pancreas looks ok for a spec PL report of 900! No blockages anywhere or lesions. The nodule on his right adrenal gland has gotten smaller, both kidneys and his spleen looked ok. Since bacteria was found in his urine when his urinalysis was done last Friday Dr Petrus performed an u/s guided cysto.

That's great news about the nodule being smaller than before :D, and no blockages or lesions in his pancreas :D:D You mentioned gallbladder a couple of pages ago, I was just reading that gallbladder sludge can cause inappetance and vomiting. Has Harley been vomiting? Or just not wanting food til yesterday? Did Dr Petrus say anything about how Harley's gallbladder looked on the u/s?


He looked at that growth on Harley's paw and gave me a rx for an antibiotic and said to wash/soak it in diluted solution of betadyne/betadine and to keep applying the triple antibiotic ointment to it. If the growth doesn't get smaller than an invasive treatment will have to be looked at.

He was stimmed again because I did start reloading him on Tuesday but had to stop on Thrusday because of his inappetence.

I really hope that the betadine/betadyne solution works, and that his little paw gets better real soon, so he (and you) can avoid further worry.
Hugs to you, Lori, and belly tickles to the boy :), you're always in our thoughts and prayers,

Jane, Franklin and Bailey xxx

[frijole]

Lori,

Checking in to see how you and Harley are doing. Sending best wishes. Kim and Annie

[Harley PoMMom]

Finally got Harley's u/s report:
Pancreas, kidneys and spleen are within normal limits.
Liver is very large but with normal parenchymal appearance.
Gall Bladder wall appeared thickened, no masses and normal bile appearance.
Both adrenal glands are prominent in size with the right one having a 0.782cm nodule seen in the caudal aspect.

The adrenal nodule has decreased in size, last time it was 0.8cm. His urine culture came back negative, which is great because the cephalexin was making him nauseated. The ACTH stim test they took, pre 8.5ug/dl and post 22.1ug/dl, so his cortisol has risen.

Dr Petrus wants to try giving Harley 250mg of Lysodren once a day to see if his tummy can handle that, we started Tuesday...this is going to be a looong load. Harley is being very fussy about eating, there is no vomiting but I can tell his belly hurts. :( I asked his GP about the Tylan and she said it would be ok to give it to him and that it might even help with that growth on his paw.

So for now we're hangin in there! Big hugs to everyone and their precious pups from Harley and me.

Love and hugs,
Lori

[littleone1]

Hi Lori,

I'm glad you got the tests results back. There are some very positive results from the tests. I hope Harley's stomach settles down, and that he will soon start eating better.

Hopefully, the once a day dosing will work for him.


Sending positive thoughts your way. Give Harley a big hug from me.

[marie adams]

Hi Lori,

I am glad you now have answers with the tests. You are a pro at this so the loading won't be that bad, but I do hope Harley feels better and will eat more.:D

Take Care of yourself also!!!!;)

[Tamarah]

Lori -

What a long week for you waiting for test results - wow - but as you said, you finally got some answers. There are some positives in the results. You have a plan - you've been at this a long time and you are very knowledgeable and very strong. I wish Harley's tum tum was feeling up to eating a bit better.

The best of wishes, thoughts, and prayers to you and Harley. :)

Tammy, Crash, & Darby

[frijole]

Lori - Glad to hear you guys are doing ok. Mostly positive results from that. I am the queen of long loads. Having seen Annie at a 19 feeling so much better - I do believe that any progress is progress so don't let the numbers get to you ok?

Re the tylan - I have four days under my belt now. :);) Definitely buy some capsules to put them in. I purchased frm the link that Natalie gave me on my thread - capsuline.com or something like that. I bought some designed for dogs! They have chicken flavor on them. Ingredients looked safe - $20 for 1000.

I can only say that this past week she has been mostly smiley so I think there is progress. I will keep you posted. Like any antibiotic there can be diarrhea but we haven't had any - in fact the anti nausea pills are still plugging her up so its helping her be more 'normal'.

Hang in there and keep us posted. We are thinking of you often. Kim and Annie

[labblab]

Lori, I've got my fingers crossed, too, that Harley's stomach will settle down and make the loading process a little bit easier on you both. As always, tons of hugs and well wishes coming your way.

Marianne

[loshie]

Hi Lori,
Hope Harley feels better real soon!! Sending lots of love and healing thoughts!
Melanie & Mila

[Franklin'sMum]

Hi Lori,
Sending love and healing thoughts to both you and Harley. Hoping his tummy issue resolves soon and our sweet boy gets his appetite back (yes, even back to gobbling your fingers!)
Love to you my dear friend,
Jane, Franklin and Bailey xxx

[Roxee's Dad]

Hi Lori,

Haven't heard how Harley is doing lately. Hope all has been going well with him.

Sending him some big Belly Rubs :)

[Harley PoMMom]

Hi John!

Harley is doing quite well, eating normally and back on his formulated diet. He is almost thru his two month wash-out period so I will soon be scheduling an ACTH stim test, CBC/Chemistry blood panel and another spec PL test to see where his levels are at on these tests. :eek: Then come Sept 13th he will start the Vetoryl at 10mg, once a day.

He hasn't needed anything for tummy upset since stopping the Lysodren. He's alert, playful and even chasing Alex the bad cat!

Of course I did not let him see the video's of Rozee's new pool because he would be sooo jealous and would want one for himself! Harley loves the water...there is a small creek where I live and I do, sometimes, let him swim in it, Bear, naturally, will have no part of creek water...Bear thinks he might get dirty or something might get on his fur! :eek::p:) Keep those video's coming, can't wait until we all see the one with the bling on her new wheels!

Love and hugs,
Lori and Harley

[Franklin'sMum]

Hi Lori,

How are you and Harley going these days? I'm sorry I missed your 13th September, but hoping and praying that Harley handles the trilo without any complications or worries.
Hugs to you my dear friend, and belly rubs to Harley :D
Jane, Franklin and Bailey xxx

[gpgscott]

Hi Lori,

I missed your last several posts also.

So have you began the Trilo treatment? How goes it?

Scott

[frijole]

:D I'm checkin in too!

[Casey's Mom]

I didn't realize you were switching either - must have missed that. Good luck and keep us posted.

Love and hugs,

[lulusmom]

I must have been asleep at the switch because I wasn't aware you were making the switch to Trilostane either. According to your post back in August, you were to start Harley on 10mg once a day. How are things going?

[Harley PoMMom]

Thanks so much for checking in on us! :)

Harley is doing great. He started 10mg Vetoryl on Saturday, 9/11. We had his stim, chemistry/CBC and spec PL done on the 7th. His pre was 3.4 ug/dl ~ post was 33.9 ug/dl and his spec PL was 547.

His next stim test/chemistry/CBC is scheduled for 9/20. Bear will be going along too, as he needs a chemistry/CBC test done also.

So, so far so good!! We will keep you all updated and hopefully the Vetoryl will get his cortisol under control with time. ;):)

Love and hugs,
Lori and Harley

[lulusmom]

With a post stim of 33.9 ug/dl, I think it was definitely safe to start the Vetoryl. Fingers and paws are crossed here that the 10mg Vetoryl will do the trick. Harley may ultimately need an increase in dose to get the cortisol within range but I think you'll get there sooner than later this time. Good luck with Bear's bloodwork and here's hoping that everything is normal.

[Squirt's Mom]

Hi Lori,

Good to know that things are going well! I hope the Trilo does the trick for your sweet boy and he is doing much better all around, even on paper ;) real soon.

I hope Bear's report is perfect!

Hugs,
Leslie and the girls :D - always

[SavingSimon]

Hi Lori and Harley,
I am thinking about switching to Lyso from trilo too, noticed that you did so without making much noise about it here - actually I don't see why you changed or when, so I was wondering how long was Harley on Trilostane and what happened? Were you not seeing results, not seeing enough results (that's where we are) or seeing bad side effects?

Just wondering why you changed your mind, if you don't mind -- because I am less scared of Lysodren the more I read, and afraid Trilostane isn't working on the most important symptoms in my dog's case.

Love to you and your boy
From me and mine.

[StarDeb55]

Dena, I think you may have misread what is going on with Harley. I don't want to put word in Lori's mouth, but since she is not on-line right now, I will answer your question. Lori has switched from lysodren to trilostane. Harley was only on a maintenance dose of lysodren, & was never loaded. This was not working so Lori, & Harley's vets felt that a switch to trilostane was needed.

Debbie

[Squirt's Mom]

Dena, Harley switched from Lyso to Trilo. You can read his thread to see what prompted this changed.

Trilostane and Vetoryl are the same drug, just generic and brand names. Lysodren and Mitotane are the same thing just in case you hear the name Mitotane in the future.

Hugs,
Leslie and the girls :D - always

[SavingSimon]

I see that I got it backwards completely.
Thank you to Frijole for letting me know first privately, I appreciate it. So I guess that is a big nevermind and oops sorry! from me. That was my moment of being a public idiot. :o


Dena, Harley switched from Lyso to Trilo. You can read his thread to see what prompted this changed.

Trilostane and Vetoryl are the same drug, just generic and brand names. Lysodren and Mitotane are the same thing just in case you hear the name Mitotane in the future.

Hugs,
Leslie and the girls :D - always

[Squirt's Mom]

No biggie! Just didn't want you get ideas from Harley that wouldn't apply to Simon. ;)

It is easy to get mixed up especially when you read so many threads a day! Plus stress makes it hard to keep things in order in our heads...I know! :rolleyes:;):D

Now that you're on the right track, you might find something of import to Simon's case in Harley's story. We are here to learn from each other, after all.

Hugs,
Leslie and the girls :D - always

[frijole]

:D Yep. I get dogs names confused, owners names confused, pretty much everything so don't worry about it, Dena. Harley won't mind. :D

[apollo6]

Hi Lori
Keep us posted on the switch. Apollo has been on Trilostane 10mg since June and has done well. Major problem is the hind leg weakness, IMO has been upping to 12.5mg compounded, not a big increase, hope will help with muscle/leg weakness.
Hugs Sonja and Apollo

[Harley PoMMom]

Harley had his stim test and CBC/Chemistry blood panel done on 9/20. His pre ~ 3.1 ug/dl and his post 11.9 ug/dl a significant drop from the 33.9 ug/dl. Unfortunately, and very worrisome, some levels on his Chemistry panel have risen. The values that are elevated indicate kidney disease/early kidney failure.

Creatinine -- 2.5 (0.4 – 1.8 mg/dL)
Phosphorus -- 8.3 (2.1 – 6.3 mg/dL)
Urea Nitrogen -- 64 (7 – 27 mg/dL)
Potassium -- 6.7 (2.1 – 6.3 mg/dL)

Harley's vet, Dr Owings, conferred with the IMS in Maryland that we had seen back in June, Dr Petrus. The decision was made to discontinue the Vetoryl and concentrate on the issue at hand, which is Harley's kidneys. The poor boy just can't get a break! :( Harley is eating good and acting normally :)...this rise in his kidney values has really totally thrown me for a loop. :eek:

Love and hugs,
Lori and Harley

[Franklin'sMum]

Hi Lori,
I've sent you a PM. Big hugs
Jane, Franklin and Bailey xxx

[frijole]

Oh Lori I am so sorry to hear this. Does the trilo effect drugs used to treat kidney issues? Sorry I am ignorant in all this. I am sending you lots of strength and big hugs. xoxoxoKim

[zoesmom]

Oh, shucks, Lori. I think trilostane is not recommended for dogs who have compromised kidney function - because it's excreted mostly thru the kidneys. I'd have to read exactly how the caution is worded but think it's mentioned in their brochure. Sue

[frijole]

Lori - I just wanted to add that it is great news that Harley is eating and feeling great. We all knows that sometimes tests are off or something affects them. Go hug Harley for me and know you are one fantastic mom.

[Harley PoMMom]

Does the trilo effect drugs used to treat kidney issues? I am sending you lots of strength and big hugs. xoxoxoKimThanks so much for hugs and strength...very much appreciated and needed!

I don't really know if trilo has any negative effects on the meds given for kidney disease but according to Dechra's Product Insert one shouldn't use Vetoryl as treatment if renal insufficiency is present.

What has me a bit confused is that his Chemistry panel done on 9/7/10 showed NO elevations in these kidneys values except the BUN. Now 13 days later and I've got a pup having levels of kidney failure. :confused:



Hi Lori,
I've sent you a PM. Big hugs


Thank You so much, Jane...Big Hugs back to you and Franklin.

[mypuppy]

Hi Lori,
I was so sorry to read this. you are absolUtely right when you say you cant catch a break. Could the trilo Have affected his values in any way? Would you consider redoing the chemistry panel while he is off the trilo and see If they go down? I don't know much about this stuff really and just trying to throw at you any little bit of help, but I am sure you've got it covered already. I hope it's nothing. I'm wishing you and little Harley a smooth ride with this and lots of healing. we love you bunches. Xo Jeanetteand Princess

[Harley PoMMom]

Hi Lori,
I was so sorry to read this. you are absolUtely right when you say you cant catch a break. Could the trilo Have affected his values in any way? Would you consider redoing the chemistry panel while he is off the trilo and see If they go down? I don't know much about this stuff really and just trying to throw at you any little bit of help, but I am sure you've got it covered already. I hope it's nothing. I'm wishing you and little Harley a smooth ride with this and lots of healing. we love you bunches. Xo Jeanetteand Princess

He has an appt. scheduled for 10/2 to have his BP checked and to get his CBC/Chemistry test done again.

I'm pretty sure the Vetoryl was the reason his levels are up, however I do believe his kidneys are diseased and the Vetoryl has had NOTHING to do with this.

Big hugs back to you and Princess...love you both much, Lori and Harley

[addy]

Hi Lori,

I sure did not expect to read about Harley and potential kidney problems. I am going to cross everything I can; fingers, toes and paws and pray the new test in October will show different results.:)

Sending positive vibes to you and Harley.

My daughter's Pom is 12 years old and still does that cute little kick and spin Pom dance; I love that dog, the poms are toooo cute:D

Hugs,

Addy

[littleone1]

Hi Lori,

I'm so sorry to hear that Harley might have kidney problems. There is always something else to worry about. The roller coaster ride continues.:(

I am glad to hear that his appetite is back and he is acting normally.

Corky and I are keeping everything crossed that his kidneys are funtioning normally.

I'm keeping you both in my thoughts and prayers that everything is okay.

(((HUGS)))

[Franklin'sMum]

Hi Lori,

Everything here that can be crossed is being crossed for you and Harley. Big hugs, love, thoughts and prayers sent your way.

Jane, Franklin and Bailey xxx

[labblab]

Hi Lori,

I, too, am so sorry for this new bump in the road!! I wish I had something constructive to offer, but I'm as puzzled as you as to why there would be such an abrupt change in Harley's labwork. I'll surely be hoping that you'll see improvement with the 10/2 results, although I know that will still leave you with a lot of question marks as far as the best way to proceed :o. You two deserve a much easier road to travel!

Beaming little Harley tons of healing thoughts, and beaming you tons of patience and strength, Lori, as you and your vet work on sorting things out. As always, you are such a wonderful mom.

Marianne

[loshie]

Hi Lori & Harley,
Sending you lots and lots of hugs and healing thoughts!

Luv,
Melanie & Mila

[apollo6]

Praying for you and Harley.
Hugs Sonja and Apollo

[Casey's Mom]

Lori, sending many positive thoughts and wishes your way.


Love and many hugs,

[Dollydog]

Hi Lori, I'm sorry to hear about the kidney issue but glad to know that Harley is still eating and behaving normally. Am hoping that those test results were not correct for some reason. Will be watching for the new results and hoping for some good news.
(((HUGS)))

[Squirt's Mom]

Hi Lori,

It's been WAY too long since we had an update on Harley. How are things at your house?

Hugs,
Leslie and the gang

[Harley PoMMom]

Oh, my dear friend, Leslie, thanks for thinking of us when you have so much going on.

Harley became ill about a month ago, he threw-up, had diarrhea and would not eat. I took him to the vet and had bloodwork done. The results have shown that his liver is failing him...his ALP is 6695 (10-150), ALT 3465 (5-107), total bilirubin 0.9 (0.0-0.4). His pancreas enzymes are also very elevated...his spec PL >1000.

His vet gave him a shot to stimulate his appetite, put him on metronidazole for the diarrhea and an antibiotic. I brought him home and he has been eating pretty good ever since and the diarrhea has stopped. Harley is still playing and taking very short walks; and I do realize that my time with my boy is coming to an end, so I am trying to make his last days, weeks, or how ever much time he has left as happy as can be.

Love and hugs,
Lori and Harley

[frijole]

Dear dear Lori... I am sorry to hear this and wish you and Harley nothing but sunshine and treats for the rest of his days. I send my love and lots of hugs to you both. Kim

[Cindy Thoman]

Lori, sorry to hear that Harley is not feeling well. Lots of positive thoughts and prayers being sent your way. Harley is adorable!

XOXO
Cindy and Alex

[labblab]

Oh Lori, I am thinking of you both, too. And hoping for some very special days with your very special boy. Sending you many hugs...

Marianne

[Casey's Mom]

Oh Lori - lots of love coming from me to you and dear Harley. I am so glad to know that Harley is having good days and that's what we all can wish for, more good days than bad.

Love to you and Harley my dear friend.

[Squirt's Mom]

Aw, honey,

This was not what I wanted to hear. :( But I am glad he is home and doing some better now.

Harley couldn't be in better hands than yours. Never doubt that or question anything you have done on his behalf. You are a super mom!

I hope you can feel our hands and arms reaching out for you, holding you, feeding you our strength and love.

Hugs, love and belly rubs,
Leslie and the gang

[BestBuddy]

Lori,

Wishing you so many of those special days.

Jenny

[mypuppy]

Dearest Lori,
I feel so sad right now and can only offer you what you have always offered all of us so effortlessly--our love, concern and support. I certainly hope your little boy will stick around a while longer--this is never easy no matter what. I hold you and your boy in my thoughts, heart and prayers. love you. Xo Jeanette

[Tamarah]

Lori -

I'm so sorry to hear of Harley's latest troubles. :( He's a super little guy and you are such a super mom! I agree totally with Leslie - Harley could not be in better hands. You're in our thoughts and prayers!

Extra special hugs and belly rubs for you and Harley!

Tammy, Crash, & Darby

[addy]

Sending lots of hugs and prayers for you and Harley.

Think of you often, Lori.

Love,
Addy

[littleone1]

Lori, my dear friend. You and Harley are in my thoughts and prayers.

Corky and I are sending you and Harley lots of hugs, love and kisses. Give Harley lots of belly rubs from his aunt.

(((((HUGS))))) I'm always here for you.

Extra love and hugs.

Terri and Corkster

[apollo6]

Dear Lori
I am so sorry to hear about Harley. You and Harley are in our prayers. Take each day as a gift with Harley.
Hugs Sonja and Apollo

[Franklin'sMum]

Lori,

I am so sorry to hear that Harley hasn't been feeling his usual spunky self. I know you are cherishing each and every moment with your special boy and I so hope you and he have much more time with each other.
Sending you both love, hugs and comfort,

Jane, Franklin and Angel Bailey xxx

[bgdavis]

Lori,

You and Harley will be in my thoughts. I know how hard it is to see our elderly ones begin to fail. Criss went through similar things during her last months with me. Love Harley and enjoy every moment.

Hugs,
Bonnie and Angel Criss Ann

[John II]

Oh Lori, I am so sorry to hear this news!
You and Harley are in my thoughts and prayers. :(

I hope you have many more good days with your little boy. ((HUGS))

[marie adams]

Hi Lori,

I am so sorry to hear about Harley. Even though we know we only have so much time left it just doesn't seem enough. I know how you will miss him because I am there on so many levels--losing my mother recently just makes how much I miss my Maddie Girl even more.

Harley is such a joy to you and you to him--enjoy every minute!!:):)

(((HUGS)))

[mytil]

((((hugs))) to you Lori and Harley.

Sending prayers your way.
Terry

[Bichonluver3]

To Lori & our Harley,
Tons of love and hugs today & everyday.
Carrol & Chloe

[lulusmom]

Hi Lori,

I was just wondering, did your vet do a liver biopsy or bile acid test? I had a Maltese who had those kind of liver values and she was diagnosed with hepatitis. She was gravely ill and I honestly didn't think she was going to make it but she did. It took her four months to recover but she got better by golly. If Harley isn't jaundiced and he is still eating, that's hugely positive considering his liver and kidney issues. When are you supposed to go back to check liver values? How is your boy doing at the moment?

(((Big Hugs)))
Glynda

[frijole]

Hugs and continued warm thoughts, Kim

[Harley PoMMom]

Hey Glynda,

His vet has not done a liver biopsy or bile acid test. I really don't think I would put Harley through a liver biopsy considering that I have not been treating his cushing's, I would be so afraid he would not survive or heal right.

Harley is not jaundiced and is still eating pretty good. I am going to reschedule to have his liver values rechecked soon.

What will a bile acid test tell me exactly? I know I have to read up on this.

Thank you all so much for your continuing prayers, hugs, love and well wishes, they do mean the world to me and my precious boy.

Love and hugs,
Lori and Harley

[Bichonluver3]

Hi Lori,
Just checking in on you guys. probably a dumb question but is Mr Harley taking Denamarin?
Love & Hugs,
Carrol

[brandysmom]

Lori,

I just read up on Harley and I'm so sorry he hasn't been feeling well. My thoughts and prayers are with you and Harley. Enjoy every minute of everyday you have together.

[lulusmom]

Hi Lori,

Here's a link the explains bile acid testing:

http://vetmedicine.about.com/od/diseasesandconditions/f/FAQ_bileacidtst.htm

After thinking about it, your vet probably didn't feel that bile acid testing is necessary since it's almost a given that with Harley's cushing's and pancreatitis, his pre and post meal bile acids will be high. You should be encouraged that Harley is eating and still enjoying his walks. I am remaining optimistic that you will see a big improvement on the next scheduled bloodwork.

Hugs,
G.

[Casey's Mom]

Lori just so you know you and Harley are in my thoughts and prayers. .

Love and many hugs,

[frijole]

Mine too. You are an angel. Harley is a lucky dog. Know that friend. Kim

[Bichonluver3]

Dear Lori,
Just checking in and sending love to you and our Harley.
Carrol & Chloe

[hfurlotte]

Hi Lori and Harley.....Zoe Claire and I are thinking about you and hope your doing ok. Sending lots of positive thoughts your way.

Heather and Zoe Claire

[Squirt's Mom]

Just dropping in to send


HUGS!!!!!!

and

BELLY RUBS!!!!!

[Harley PoMMom]

I just had Harley to the vets today as he was having labored breathing and gagging sometimes. It seems after the examination and X-rays his heart is now failing him. He got a shot to help him relieve the fluid that is there and we are seeing his vet on Monday.

Thanks so much for your prayers and positive thoughts, they are so very appreciated.

Love and hugs,
Lori and Harley

[labblab]

Oh Lori. You and Harley will remain in my thoughts and prayers. I am so sorry for this new setback. Please tell Harley that his whole family here loves him very much.

Sending many hugs to you both,
Marianne

[Cindy Thoman]

Lori, so terribly sorry to hear about Harley's setback. Our thoughts and prayers are with you. He is just so adorable, give him a kiss from us!!

XOXO
Cindy, Alex, and Bear

[addy]

We are here too, Lori, saying lots of prayers Harley pulls through this set back just fine.

Love to you both,

Addy, Zoe and Koko

[lulusmom]

Lori, my heart and prayers are with you and Harley.

[littleone1]

Lori, my very dear friend, my thoughts and prayers are with you and Harley. I'm sending lots of love and hugs to you and Harley. Corky is sending you and Harley lots of kisses.

I'm sending positive thoughts that the shot really helps Harley.

Lots of love and more hugs.

Terri and Corky

[Roxee's Dad]

Dear Lori,
Sending heartfelt prayers and well wishes for our Harley boy. Give him a gentle pat on the head from me.

(((HUGS)))

[marie adams]

Hi Lori,

Sending my prayers and wished for Harley's fight to overcome yet another setback.

Please take care of yourself also. Big (((HUG))) for you and Harley too!!!:D

[Spiceysmum]

Lori,

Thinking of you and Harley.

Linda x

[Casey's Mom]

Lori you are in my thoughts and prayers this weekend and dear Harley too. Blessings going out to you my dear friend,

Love and many hugs,

[cairncrazy24]

Lori... sending good thoughts and prayers to you and Harley!

{{{{Hugs}}}}}}

[frijole]

Dear dear Lori... I was out of town and just read your post about Harley. Like everyone else I am sending prayers, strength, warmest thoughts, love and big bear hugs to you and sweet Harley. Love, Kim

[Franklin'sMum]

Dearest Lori,

I'm sending you both my prayers, thoughts and lots of love. I so hope Harley overcomes this latest setback and you have so much more time together.

Big HUGS,
Jane, Franklin and Angel Bailey xxx

[Harley PoMMom]

My dear friends,

It is with a heavy heart that I let you know that Harley, my sweet boy, has passed.

Please give your furbabies extra hugs and kisses in memory of my dear boy.

With love,
Lori

[StarDeb55]

Lori, words are very inadequate at this time. Just know that I'm thinking about you.

Debbie

[Cindy Thoman]

Oh Lori, I am so so sorry to hear about Harley. My thoughts and prayers are with you. Being a pom lover this makes me extra sad. I was just looking at his pictures again and I love the frisbee one. What a beautiful face!
Love,
Cindy, Alex and Bear

[labblab]

Oh Lori. There are just no words. I am so sorry.

Holding Harley in my prayers, and holding you in my heart.
Marianne

[frijole]

Lori, Tears are flowing and my heart breaks with yours. You were the bestest mom ever to our dear Harley. He will forever be honored here and in all of our hearts. Please know that. Our newest angel is now free to run without pain. RIP dear sweet Harley boy. Love, Aunt Kim

[Casey's Mom]

Lori - my dear friend. Words are not there for me now although my heart is with you. Sweet Harley, that little face was one of the first to greet me and help me through this journey. I love that face. I wish my arms could stretch that far to hug you Lori.

My tears are with you,

[littleone1]

Lori, my very dear friend, I am so very sorry to hear about Harley. You did everything you could possibly do for him. I know that down deep in your heart, you know you did what was best for Harley. I know you didn't want him to suffer. Harley knows how very much you loved him. He had the best mom.

Take care. Please give me a call when you feel like talking.

Corky and I love you very much. You are a very special friend.

I'm sending tons of hugs and love to you and lots of kisses from Corky. You are in my thoughts and prayers.

Luv ya bunches,

Terri and Corkster

[Tamarah]

Lori -

I'm writing through my tears of the news. There are not words enough to comfort you at this time I'm sure. I am just so sorry for your loss. Know that your sweet baby boy Harley had the best mom without a doubt! Your family is here for you my dear friend.

God speed to you Harley.

Hugs and prayers!

Tammy, Crash, & Darby

[jmac]

I am so sorry to hear you lost Harley. You're in my thoughts...

Julie

[gpgscott]

Dear Lori,

Mine will all get very special hugs and kisses tonight in memory of your Harley.

Godspeed Harley.

Scott

[marie adams]

Dear Lori,

I am so sorry to hear of your loss of Harley. I so remember typing the words to let you all know about Maddie so I know how hard it is. (((HUG)))

Please take care and know they are all flocking in the zinnias (Maddie's favorite) with all the pretty colors. Harley is in good hands or should I say paws with all the Cushings babies.:)

Sweet Harley!!!

[loshie]

I'm so very sorry to hear the sad news, my thoughts and prayers are with you.
Big hugs,
Melanie

[apollo6]

Dear Lori
I am reading with sadness. I am so sorry for the loss of yuoir beloved Harley.
this was from Cory's Mom
The Fourth Day
by Martin Scot Kosins

If you ever love an animal, there are three days in your life you will always remember.
The first is a day, blessed with happiness, when you bring home your young new friend.
You may have spent weeks deciding on a breed. You may have asked numerous opinions of many vets, or done long research in finding a breeder. Or, perhaps in a fleeting moment, you may have just chosen that silly looking mutt in a shelter ... simply because something in its eyes reached your heart.
But when you bring that chosen pet home, and watch it explore, and claim its special place in your hall or frontroom - and when you feel it brush against you for the first time - it instills a feeling of pure love you will carry with you through the many years to come.

The second day will occur eight or nine or ten years later.
It will be a day like any other. Routine and unexceptional. But, for a surprising instant, you will look at your longtime friend and see age where you once saw youth.
You will see slow deliberate steps where you once saw energy.
And you will see sleep where you once saw activity.
So you will begin to adjust your friend's diet - and you may add a pill or two to her food.
And you may feel a growing fear deep within yourself, which bodes of a coming emptiness.
And you will feel this uneasy feeling, on and off, until the third day finally arrives.

And on the third day - if your friend and God have not decided for you, then you will be faced with making a decision of your own - on behalf of your lifelong friend, and with the guidance of your own deepest Spirit.
But whichever way your friend eventually leaves you - you will feel as alone as a single star in the dark night sky.

If you are wise, you will let the tears flow as freely and as often as they must. And if you are typical, you will find that not many in your circle of family or human friends will be able to understand your grief, or comfort you.
But if you are true to the love of the pet you cherished through the many joyfilled years, you may find that a soul - a bit smaller in size than your own - seems to walk with you, at times, during the lonely days to come.
And at moments when you least expect anything out of the ordinary to happen, you may feel something brush against your leg - very very lightly.
And looking down at the place where your dear, perhaps dearest, friend used to lay - you will remember those three significant days.
The memory will most likely be painful, and leave an ache in your heart -
As time passes the ache will come and go as if it has a life of its own.
You will both reject it and embrace it, and it may confuse you.
If you reject it, it will depress you.
If you embrace it, it will deepen you.
Either way, it will still be an ache.

But there will be, I assure you, a fourth day when - along with the memory of your pet - and piercing through the heaviness in your heart -there will come a realization that belongs only to you.
It will be as unique and strong as our relationship with each animal we have loved, and lost.
This realization takes the form of a Living Love -
Like the heavenly scent of a rose that remains after the petals have wilted, this Love will remain and grow - and be there for us to remember.
It is a Love we have earned.
It is the legacy our pets leave us when they go -
And it is a gift we may keep with us as long as we live.
It is a Love which is ours alone -
And until we ourselves leave, perhaps to join our Beloved Pets -

It is a Love that we will always possess.
Sending loving thoughts
Sonja and Apollo

[corgipallie]

Lori I am so sorry to hear about Harley. :( You are in my thoughts and prayers. You were here when my Pallie was sick and passed away and I am here for you at this very sad time.

Steph

[lulusmom]

Lori, I don't even know where to begin to find the words to express how sorry I am to hear of Harley's passing. My heart breaks with yours and my tears fall with yours. He was an amazing little Pommie boy who was incredibly lucky to have you as his mom and vice versa. I will always hold his memory close.

Godspeed Sweet Harley.

[BestBuddy]

Lori I am so sorry. There are no words so I hope you can hear my heart talking to you.

Jenny

[John II]

Dearest Lori,

I am so sorry to hear this news. :'-(

I hope you can find some comfort in knowing, as I did, that you did everything you could to give Harley the best quality of life possible. You worried, you researched, you pursued every option. How many puppies out there are so lucky to have someone care so much?

Harley was blessed to have you, and now Angelina is welcoming him to his new home, showing him the ropes, and getting him settled in.

Huge bear hugs to you Lori. :(