cbording
05-18-2011, 06:03 PM
Hello, and I'm hoping you can give some advice/reassurance. I've spoken of my male Dachshund Joey on here before, who had a bilateral adrenalectomy, but this is about his littermate sister, Maggie, who has pituitary dependent Cushings.
She weighs 20 pounds. We started her on 30 mg Vetoryl/day and were doing OK, but then her levels came back very high, so we doubled her dose to 30 mg every 12 hours. She also had a pancreatitis attack before her dose was doubled, and we nearly lost her.
It's been about 6 weeks since her pancreatitis attack, and she is doing great and tolerating 30 mg Q12H well. She runs around like a puppy, which she hasn't done in some time.
Just got new ACTH stim test results today and they were 2.2 pre and 9.6 post. The doc wants to just slightly increase her dose by 10 mg/day. His goal is to get her post test < 7.6. I see in a study on twice daily trilostane dosing that this is a goal in that study, but everywhere else I read, it's 5.5? What are your thoughts on this?
I know her dose is possibly getting kind of high - it will be 70 mg/day - what are some max mg/kg doses that you see on dogs here? At what point should I be worried that her dose is too high? Is 10 mg increase aggressive enough based on her levels?
I work 10-6:30, so I give her doses with meals usually at 9 AM and 7 PM (I've tried to give her evening dose at a more appropriate interval, but then I kept forgetting it, or giving it to her at 2 AM in the middle of the night when I would remember). So, I am going to give her 30 mg at 9 AM and 40 mg at 7 PM (where there is a 2-hour longer interval).
Thoughts?
Thanks much,
Carson, Joey, and Maggie.....
She weighs 20 pounds. We started her on 30 mg Vetoryl/day and were doing OK, but then her levels came back very high, so we doubled her dose to 30 mg every 12 hours. She also had a pancreatitis attack before her dose was doubled, and we nearly lost her.
It's been about 6 weeks since her pancreatitis attack, and she is doing great and tolerating 30 mg Q12H well. She runs around like a puppy, which she hasn't done in some time.
Just got new ACTH stim test results today and they were 2.2 pre and 9.6 post. The doc wants to just slightly increase her dose by 10 mg/day. His goal is to get her post test < 7.6. I see in a study on twice daily trilostane dosing that this is a goal in that study, but everywhere else I read, it's 5.5? What are your thoughts on this?
I know her dose is possibly getting kind of high - it will be 70 mg/day - what are some max mg/kg doses that you see on dogs here? At what point should I be worried that her dose is too high? Is 10 mg increase aggressive enough based on her levels?
I work 10-6:30, so I give her doses with meals usually at 9 AM and 7 PM (I've tried to give her evening dose at a more appropriate interval, but then I kept forgetting it, or giving it to her at 2 AM in the middle of the night when I would remember). So, I am going to give her 30 mg at 9 AM and 40 mg at 7 PM (where there is a 2-hour longer interval).
Thoughts?
Thanks much,
Carson, Joey, and Maggie.....