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View Full Version : Walter,12 y.o. Shiba Inu with Cushing's - Lysodren



walters mom
11-09-2010, 07:58 PM
Admin Note: Moved from the How To section.

Hi, my name is Leanne, Walter our 12 year old shiba inu was diagnosed with cushings about 2 months ago. It started when I noticed that his front teeth had broken off while gnawing a bone and took him in to the vet. They wanted to put him under anesthetic and the routine blood work showed abnormal levels that suggested cushings so they tested for it and it came back positive. He had been drinking alot, peeing more and panting, but his appetite was good...although he was slowing down quite a bit, I assumed it was the hot summer and that he was aging. We immediately tried to find as much info as possible while the vet put him on a loading phase of lysodren. After about 5 days, he started to fall down and vomit. The emergency vet gave him prednisone but said to NOT stop the lysodren (against my gut feeling). A day later, the original vet said he should have been taken off the lysodren. He had a follow up test and the levels were down and the cortisol levels were of course too low. I switched clinics at this point. I realize it is a hard thing to navigate, but I am acutely aware of those important little changes that we as pet owners can notice and act upon. The new vet is much more positive and we've started on a maintenance schedule of lysodren once weekly. So far, from the first couple of days of the loading phase, all of the cushings symptoms except the hair loss have gone. He has had his dental surgery and I am sure feels much better from that alone. Lately the only awkward thing is excessive licking around his bum and inner legs. And he seems itchy. I am wondering if it is his diet? He was eating orijen fish kibble and natural balance canned. But now he won't touch the kibble and is very picky about the flavours of his wet food. ( He was always food oriented and not difficult to feed). I am thinking that raw would be the best thing for him, I used to do that in the past, but he turned out to be allergic to chicken. Regardless, I am so happy to have stumbled upon this forum, we are trying so hard to make sure we do the right things for Walt and keep him as comfortable and happy as possible.

frijole
11-09-2010, 11:21 PM
Hi and welcome! You will be glad to know that some dogs do become picky eaters after lysodren and things they used to eat they no longer do. I also think the licking could be cushings related, or pain. When you reduce cortisol in these older dogs you are taking away their natural 'pain pill' and so often they require meds or glucosamine for arthritis. Licking can be a sign of pain.

You didn't indicate the timeline between when your dog went 'low' and when he started back up on the maintenance level. Usually acth tests are done and time is allowed for cortisol production to go back up to a 'normal' level. (between 1 and 5 on the acth test for cush dogs). Can you give us more info on that? Because if the levels are still low that might be the problem with the appetite.

Best of luck. Kim

walters mom
11-09-2010, 11:59 PM
Hi! Thanks for such a speedy reply. He had his second ACHT test done after 8 days of lysodren twice a day and then 2 days of nothing. After those results, they said to do nothing for 14 days and come back for another ACHT. During the first week of nothing, he was good some days and really lethargic others ( I gave him a bit of prednisone on those days ). After a week I took him to the new vet because I just wasn't confident with the lack of communication and care. The new vet had all of the test results and after checking him, decided that we should address his teeth, they were causing him a lot of distress and he really changed for the better after the surgery. We did this during the second week of no lysodren. He started the lysodren the following week. So far, he is prescribed 3/4 of a tablet of the lysodren once a week for 8 weeks and it has been 2 weeks. (he is 26 pounds) We'll do another test then to see where he is at. I fed him salmon with no grains or additives tonight and he hasn't been licking or rubbing his snout...so far so good!http://www.k9cushings.com/forum/images/icons/icon7.gif

frijole
11-10-2010, 12:12 AM
Great, that is what I wanted to hear... most will wait two weeks and test. Is the current dosage smaller than the amount you loaded on?
You now know the signs of overdose are vomit/diarrhea but before that happens they quit eating and stools are soft so keep the eyes open. Checking again in 8 weeks is OK but if you see anything unusual, stop giving lysodren, call the vet and test. Better safe than sorry.

Also in case they didn't tell you, never give lysodren to a sick dog. My girl Haley was on it for 4 yrs and she passed in May and was over 16 so Walter can have a great life. (she did not die from cushing's) Its just important to understand the drug and as you know, have an experienced vet in your corner.

Are you giving the drug all at one time (weekly) or are you splitting it up over the course of the week? Tell us more about Walter when you have time. Glad you found us. Kim

walters mom
11-10-2010, 01:18 PM
His loading dosage was 1and1/4 tablet per day, split up between morning and evening. Now his maintenance dosage is 3/4 of a tablet once weekly. I took the day off work the first time I gave it to him to watch if there were any troubling behaviors and he has seemed completely unaffected by it. Just the picky eating. He is no longer drinking water like it's going out of style and he is alert and engaged, even playing again! I'm often overly sensitive to how quick/slow his reactions are but he does like to sleep and takes a bit longer to get up. It could be the lower cortisol levels that are allowing him to feel more pain than before. I was thinking about glucosamin, I take it myself and I'm pretty sure it helps me, how much should I give him? and does it have to be a specific kind for pets?
I am so happy to hear that many dogs continue to live out their lives, it is heartening. It is also a relief to communicate with people who truly understand, thank you!

Casey's Mom
11-10-2010, 01:53 PM
Once the cortisol levels are controlled and if the pup has arthritis issues which my dog has they will show up.

My girl Casey gets monthly Adequan injections from the vet, also L-Glutamine, Glucosamine and Salmon Oil and all of those have helped her have a great level of activity at 14 1/2. Be aware that all of these take some time to build up in their system so that you can begin to see some improvement. Also you should talk to your vet about the dosage and recommendations for your dog.

Hugs,

walters mom
11-12-2010, 03:03 PM
It is week 3 of the maintenance and this time Walter was hungrier than usual the day before he had his weekly 3/4 of a tablet.. after, he was extremely tired and had some trouble walking with his little back hips swaying. I immediately gave him prednisone and it cleared up right away. Now he is back to normal. I think that I will split the dose up so that he receives 1/2 a tablet twice a week. He has also been shedding ALOT. Shibas have a double coat and I am used to the normal shedding of the undercoat that he does twice a year. But this seems to be the topcoat and it is getting quite thin. This is the season that he should be growing his undercoat and getting really puffy. Is hair loss a symptom of the lysodren as well as the cushings?

walters mom
03-29-2011, 03:49 PM
just an update... Walter is doing very well! He has been on the maintenance dose of lysodren for about 5 months now. His coat did become very thin and sparse, but grew back thicker and fuzzier than ever. All of the cushings symptoms have disappeared. Weight is good, eating and drinking normally. Once in awhile, he seems very low energy after the medication and I give him a bit of prednisone and he perks right up. Recently, he had a bout of colitis and since that has cleared up, he is happy and healthy. We are really thankful for all of the information and experiences on this site. It has helped us maintain a positive attitude about this disease and how to live with it.

lulusmom
03-29-2011, 07:23 PM
That is great news! Isn't it great to watch the dramatic improvements in our our babies brought about by the medication? I love it and I'm elated to hear that Walter is doing so well, thick fuzzy coat and all. :D

Glynda